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Review
. 2021 Nov 2:15:4503-4525.
doi: 10.2147/DDDT.S327378. eCollection 2021.

Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

Ying Peng  1 , Mingyue Ao  1 , Baohua Dong  1 , Yunxiu Jiang  1 , Lingying Yu  1 , Zhimin Chen  1 , Changjiang Hu  1   2 , Runchun Xu  1
Affiliations
Review

Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

Ying Peng et al. Drug Des Devel Ther. .

Abstract

Curcumin is a natural compound with great potential for disease treatment. A large number of studies have proved that curcumin has a variety of biological activities, among which anti-inflammatory effect is a significant feature of it. Inflammation is a complex and pervasive physiological and pathological process. The physiological and pathological mechanisms of inflammatory bowel disease, psoriasis, atherosclerosis, COVID-19 and other research focus diseases are not clear yet, and they are considered to be related to inflammation. The anti-inflammatory effect of curcumin can effectively improve the symptoms of these diseases and is expected to be a candidate drug for the treatment of related diseases. This paper mainly reviews the anti-inflammatory effect of curcumin, the inflammatory pathological mechanism of related diseases, the regulatory effect of curcumin on these, and the latest research results on the improvement of curcumin pharmacokinetics. It is beneficial to the further study of curcumin and provides new ideas and insights for the development of curcumin anti-inflammatory preparations.

Keywords: anti-inflammatory; atherosclerotic; osteoarthritis; pharmacokinetics; prodrug; psoriasis.

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Conflict of interest statement

ChangJiang Hu is an employee of Neo-Green Pharmaceutical Co., Ltd. The authors report no other potential conflicts of interest for this work.

Figures

Figure 1
Figure 1
Chemical structure of curcuminoids (include curcumin, demethoxycurcumin, bisdemethoxycurcumin).
Figure 2
Figure 2
The regulatory effect of curcumin on inflammatory signaling pathway.
Figure 3
Figure 3
The effect of curcumin on IBD, arthritis, psoriasis, depression and atherosclerosis.
Figure 4
Figure 4
Chemical structure of curcumin-related products. (A) Curcumin degradation products; (B) curcumin metabolites.
See this image and copyright information in PMC

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