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Review
. 2021 Oct 5:18:100361.
doi: 10.1016/j.bbih.2021.100361. eCollection 2021 Dec.

Roles of calcitonin gene-related peptide in the skin, and other physiological and pathophysiological functions

Yee Jung Kim  1 , Richard D Granstein  1
Affiliations
Review

Roles of calcitonin gene-related peptide in the skin, and other physiological and pathophysiological functions

Yee Jung Kim et al. Brain Behav Immun Health. .

Abstract

Skin immunity is regulated by many mediator molecules. One is the neuropeptide calcitonin gene-related peptide (CGRP). CGRP has roles in regulating the function of components of the immune system including T cells, B cells, dendritic cells (DCs), endothelial cells (ECs), and mast cells (MCs). Herein we discuss actions of CGRP in mediating inflammatory and vascular effects in various cutaneous models and disorders.

Keywords: CGRP; Calcitonin gene-related peptide; Cutaneous disorders; Immunoregulation; Neurogenic inflammation; Skin immunity; Therapeutic target.

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Conflict of interest statement

RDG is on the scientific advisory boards of Elysium Health and Hoth Therapeutics. He is also on the Industry Advisory Board of Gore Range Capital and has research agreements with Leo Pharma, the Leo Foundation, Galderma, Pfizer and Elysium Health.

Figures

Fig. 1
Fig. 1
Effect of CGRP on the heart, the brain, the skin and vessels. CGRP impacts monocytes, macrophages, LCs, dendritic cells, endothelial cells, vascular smooth muscle and neutrophils, along with epidermal cells such as keratinocytes, melanocytes, and fibroblasts, likely contributing to a number of disease states, as described in the text. EMT, epithelial-mesenchymal transition; FMT, fibroblast to myofibroblast transdifferentiation; APC, antigen presenting cell; LC, Langerhans Cell; DC, dendritic cell. Created with BioRender.com. (single column fitting image).
Fig. 2
Fig. 2
Probable Roles of CGRP in inflammatory skin disorders. TRPA1, transient receptor potential ankyrin 1; TRPV1, transient receptor potential vanilloid 1; CGRP, calcitonin gene-related peptide; MC, mast cell; ETR, erythematotelangiectatic subtype of rosacea; CNS, central nervous system; CHS, contact hypersensitivity; DC, dendritic cells; BoNT-A, botulinum neurotoxin A. Created with BioRender.com. (single column fitting image).
See this image and copyright information in PMC

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