Immune and non-immune functions of adipose tissue leukocytes

doi:10.1038/s41577-021-00635-7

Review

. 2022 Jun;22(6):371-386.

doi: 10.1038/s41577-021-00635-7. Epub 2021 Nov 5.

Immune and non-immune functions of adipose tissue leukocytes

W V Trim^{1

2}, L Lynch^{3

4}

Affiliations

¹ School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
² Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
³ School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. llynch@bwh.harvard.edu.
⁴ Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. llynch@bwh.harvard.edu.

PMID: 34741167
DOI: 10.1038/s41577-021-00635-7

Review

Immune and non-immune functions of adipose tissue leukocytes

W V Trim et al. Nat Rev Immunol. 2022 Jun.

. 2022 Jun;22(6):371-386.

doi: 10.1038/s41577-021-00635-7. Epub 2021 Nov 5.

Authors

W V Trim^{1

2}, L Lynch^{3

4}

Affiliations

¹ School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
² Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
³ School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. llynch@bwh.harvard.edu.
⁴ Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. llynch@bwh.harvard.edu.

PMID: 34741167
DOI: 10.1038/s41577-021-00635-7

Abstract

Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence. Much of the work into understanding the role of immune cells in adipose tissue has been in the context of obesity. These investigations have also uncovered a range of typical (immune) and non-typical functions exerted by adipose tissue leukocytes. Here we provide an overview of the adipose tissue immune system, including its role as an immune reservoir in the whole-body response to infection and as a site of parasitic and viral infections. We also describe the functional roles of specialized immunological structures found within adipose tissue. However, our main focus is on the recently discovered 'non-immune' functions of adipose tissue immune cells, which include the regulation of adipocyte homeostasis, as well as responses to changing nutrient status and body temperature. In doing so, we outline the therapeutic potential of the adipose tissue immune system in health and disease.

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References

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[1] v. Recklinghausen, F. Ueber Eiter-und Bindegewebskörperchen. Arch. Pathol. Anat. 28, 157–197 (1863). - DOI

[2] v. Recklinghausen, F. Ueber Eiter-und Bindegewebskörperchen. Arch. Pathol. Anat. 28, 157–197 (1863). - DOI

[3] Ranvier, L. Du dévelopment et de l’accroissement desvaiseaux sanguins. Arch. Physiol. Norm. Pathol. 6, 429–446 (1874).

[4] Ranvier, L. Du dévelopment et de l’accroissement desvaiseaux sanguins. Arch. Physiol. Norm. Pathol. 6, 429–446 (1874).

[5] Wertheimer, E. & Shapiro, B. The physiology of adipose tissue. Physiol. Rev. 28, 451 (1948). - PubMed - DOI

[6] Wertheimer, E. & Shapiro, B. The physiology of adipose tissue. Physiol. Rev. 28, 451 (1948). - PubMed - DOI

[7] Hotamisligil, G. S., Shargill, N. S. & Spiegelman, B. M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science https://doi.org/10.1126/science.7678183 (1993). This is the first study to identify adipose tissue as a source of inflammation in obesity, which is a direct contributing factor in the development of obesity-associated insulin resistance. - DOI - PubMed

[8] Hotamisligil, G. S., Shargill, N. S. & Spiegelman, B. M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science https://doi.org/10.1126/science.7678183 (1993). This is the first study to identify adipose tissue as a source of inflammation in obesity, which is a direct contributing factor in the development of obesity-associated insulin resistance. - DOI - PubMed

[9] Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432 (1994). - PubMed - DOI

[10] Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432 (1994). - PubMed - DOI

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Immune and non-immune functions of adipose tissue leukocytes

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Immune and non-immune functions of adipose tissue leukocytes

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Abstract

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