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. 1987 Jun;84(12):4131-4.
doi: 10.1073/pnas.84.12.4131.

Increased radiation-induced transformation in C3H/10T1/2 cells after transfer of an exogenous c-myc gene

V Sorrentino, V Drozdoff, L Zeitz, E Fleissner

Increased radiation-induced transformation in C3H/10T1/2 cells after transfer of an exogenous c-myc gene

V Sorrentino et al. Proc Natl Acad Sci U S A. 1987 Jun.

Abstract

C3H/10T1/2 cells were infected with a retroviral vector expressing a mouse c-myc oncogene and a drug-selection marker. The resulting cells, morphologically indistinguishable from C3H/10T1/2, displayed a greatly enhanced sensitivity to neoplastic transformation by ionizing radiation or by a chemical carcinogen. Constitutive expression of myc therefore appears to synergize with an initial carcinogenic event, providing a function analogous to a subsequent event that apparently is required for the neoplastic transformation of these cells. This cell system should prove useful in exploring early stages in radiation-induced transformation.

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