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. 2021 Oct 3;12(23):6931-6936.
doi: 10.7150/jca.63333. eCollection 2021.

Clinicopathological Significance of ATRX Expression in Nasopharyngeal Carcinoma Patients: A Retrospective Study

Yangchun Xie  1 , Haihua Wang  2 , Sisi Wang  1 , Yuhua Feng  1 , Yeqian Feng  1 , Songqing Fan  2 , Chunhong Hu  1 , Xianling Liu  1 , Tao Hou  1
Affiliations

Clinicopathological Significance of ATRX Expression in Nasopharyngeal Carcinoma Patients: A Retrospective Study

Yangchun Xie et al. J Cancer. .

Abstract

Background: Nasopharyngeal carcinoma (NPC) is the most common head and neck squamous cell carcinoma in south China. Radiation technology improves the local control rates in early NPC. However, the distant metastases are still the main cause of treatment failure. Thus, to find biomarkers for prognosis will help to enhance the survival of NPC. ATRX is a chromatin remodeling protein localized in the nucleus. Deletion or mutation of ATRX gene has been demonstrated in a variety of malignancies. However, the significance of ATRX expression in the prognosis of NPC remains unclear. Methods: Tumor tissues from 227 NPC patients diagnosed in the Second Xiangya Hospital of Central South University from 2011 to 2016 were selected. Immunohistochemistry was used to detect the ATRX expression level of the tumor tissue. Chi-square test was used to analyze the relationship between ATRX expression and clinical characteristics such as age, sex, T stage, N stage and clinical stage. Kaplan-Meier method was used for survival analysis, and log-rank was used to compare the difference in survival rate. Results: There were 53 patients with negative ATRX expression, accounting for 24.2% of the total group. ATRX expression was not significantly associated with age, sex, N stage, clinical stage, and progression-free survival (PFS) (P>0.05). However, patients with negative ATRX expression had earlier T staging (P=0.045) and a higher 5-year overall survival (84.9% vs 66.9%, P=0.022). Conclusions: Loss of ATRX expression may contribute to better prognosis in patients with NPC.

Keywords: ATRX; Nasopharyngeal Carcinoma; Prognosis; Staging; Survival.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Immunohistochemical study of ATRX expression in NPC tissues. The intensity of nucleus staining was graded as negative (A) or positive (B) (A-B, ×200).
Figure 2
Figure 2
Kaplan-Meier survival curves of patients with NPC stratified by ATRX expression. (A) Progression-free survival and (B) overall survival according to ATRX expression in NPC patients. ATRX negative (n=53) and ATRX positive (n=174).
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