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Review
. 2021 Dec:240:123-136.
doi: 10.1016/j.imlet.2021.10.007. Epub 2021 Oct 29.

Gene regulation of intracellular adhesion molecule-1 (ICAM-1): A molecule with multiple functions

Mona Singh  1 , Mony Thakur  2 , Manish Mishra  3 , Manisha Yadav  3 , Rajkamal Vibhuti  2 , Athira M Menon  4 , Girima Nagda  5 , Ved Prakash Dwivedi  6 , Tikam Chand Dakal  4 , Vinod Yadav  2
Affiliations
Review

Gene regulation of intracellular adhesion molecule-1 (ICAM-1): A molecule with multiple functions

Mona Singh et al. Immunol Lett. 2021 Dec.

Abstract

Intracellular adhesion molecule 1 (ICAM-1) is one of the most extensively studied inducible cell adhesion molecules which is responsible for several immune functions like T cell activation, extravasation, inflammation, etc. The molecule is constitutively expressed over the cell surface and is regulated up / down in response to inflammatory mediators like cellular stress, proinflammatory cytokines, viral infection. These stimuli modulate the expression of ICAM-1 primarily through regulating the ICAM-1 gene transcription. On account of the presence of various binding sites for NF-κB, AP-1, SP-1, and many other transcription factors, the architecture of the ICAM-1 promoter become complex. Transcription factors in union with other transcription factors, coactivators, and suppressors promote their assembly in a stereospecific manner on ICAM-1 promoter which mediates ICAM-1 regulation in response to different stimuli. Along with transcriptional regulation, epigenetic modifications also play a pivotal role in controlling ICAM-1 expression on different cell types. In this review, we summarize the regulation of ICAM-1 expression both at the transcriptional as well as post-transcriptional level with an emphasis on transcription factors and signaling pathways involved.

Keywords: Chromatin modification; Cytokines; ICAM-1; Inflammation.

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