doi: 10.1016/0092-8674(87)90567-8.
A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product
- PMID: 3471350
- DOI: 10.1016/0092-8674(87)90567-8
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A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product
Cell.
.
Abstract
We have identified in mice an allele of a new T cell receptor V beta gene, V beta 17a, whose product is bound by the monoclonal antibody KJ23a. Over 90% of T cell hybridomas prepared from V beta 17a+ T cells of SWR mice respond to allogeneic forms of the IE class II MHC protein, indicating that V beta 17a has an appreciable affinity for IE regardless of the other components of the T cell receptor. These results suggest a bias in the germ-line T cell receptor repertoire toward recognition of MHC proteins and indicate that the V beta portion of the receptor may form the most important contact points with MHC ligands.
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