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Review
. 2021 Oct 7:2021:7796727.
doi: 10.1155/2021/7796727. eCollection 2021.

Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence

Habib Yaribeygi  1 , Mina Maleki  2 , Thozhukat Sathyapalan  3 , Tannaz Jamialahmadi  4   5 , Amirhossein Sahebkar  6   7   8
Affiliations
Review

Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence

Habib Yaribeygi et al. J Diabetes Res. .

Abstract

The modern lifestyle has a negative impact on health. It is usually accompanied by increased stress levels and lower physical activity, which interferes with body homeostasis. Diabetes mellitus is a relatively common metabolic disorder with increasing prevalence globally, associated with various risk factors, including lower physical activity and a sedentary lifestyle. It has been shown that sedentary behavior increases the risk of insulin resistance, but the intermediate molecular mechanisms are not fully understood. In this mechanistic review, we explore the possible interactions between physical inactivity and insulin resistance to help better understand the pathophysiology of physical inactivity-dependent insulin resistance and finding novel interventions against these deleterious pathways.

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Conflict of interest statement

The authors declare that they have no conflict of interest in this study.

Figures

Figure 1
Figure 1
Simple schematic pic of insulin signal transduction (IRSs = insulin receptor substrates; PI3K = phosphoinositide 3-kinase; PIP2 = phosphatidylinositol 4,5-bisphosphate; PIP3 = phosphatidylinositol 3,4,5-trisphosphate; Akt = protein kinase B; Glut-4 = glucose transporter type 4).
Figure 2
Figure 2
Possible links between physical inactivity and insulin resistance.
See this image and copyright information in PMC

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References

    1. Zghebi S. S., Steinke D. T., Carr M. J., Rutter M. K., Emsley R. A., Ashcroft D. M. Examining trends in type 2 diabetes incidence, prevalence and mortality in the UK between 2004 and 2014. Diabetes, Obesity and Metabolism . 2017;19(11):1537–1545. - PubMed
    1. Eid S., Sas K. M., Abcouwer S. F., et al. New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism. Diabetologia . 2019;62(9):1539–1549. doi: 10.1007/s00125-019-4959-1. - DOI - PMC - PubMed
    1. Wu T., Qiao S., Shi C., Wang S., Ji G. Metabolomics window into diabetic complications. Journal of diabetes investigation . 2018;9(2):244–255. doi: 10.1111/jdi.12723. - DOI - PMC - PubMed
    1. Yaribeygi H., Atkin S. L., Simental-Mendía L. E., Sahebkar A. Molecular mechanisms by which aerobic exercise induces insulin sensitivity. Journal of Cellular Physiology . 2019;234(8):12385–12392. doi: 10.1002/jcp.28066. - DOI - PubMed
    1. Petersen M. C., Shulman G. I. Mechanisms of insulin action and insulin resistance. Physiological Reviews . 2018;98(4):2133–2223. doi: 10.1152/physrev.00063.2017. - DOI - PMC - PubMed