Advances in multifunctional chitosan-based self-healing hydrogels for biomedical applications
- PMID: 34611684
- DOI: 10.1039/d1tb01363g
Advances in multifunctional chitosan-based self-healing hydrogels for biomedical applications
Abstract
Multifunctional self-healing hydrogels have recently attracted considerable interest in biomedical applications owing to their diverse properties, including self-healing, adhesion, conduction, antibacterial, and stimulus-response, which can meet various application requirements, ranging from wound dressings and delivery vehicles to the production of scaffolds for tissue repair and regeneration. As a natural polycationic polysaccharide with good biocompatibility, chitosan is widely used in hydrogel formation as there are many amino and hydroxyl groups along the chains that can actively participate in various physical effects and chemical reactions, which enable it to construct self-healing hydrogels and fulfill multiple functions. In this review, the formation of chitosan-based self-healing hydrogels and the related self-healing mechanism are summarized, including Schiff base, metal coordination, ionic and hydrogen bonds, hydrophobic and host-guest interactions, with a focus on the strategies for their multi-functionalization. In the last section, the applications of the chitosan-based self-healing hydrogels in the fields of wound dressings, delivery vehicles, scaffolds, and biological sensors are discussed. Overall, it is highly expected that this review could provide an insight into the prospective development of multifunctional self-healing hydrogels for biomedical applications.
Similar articles
-
Chitosan-based hydrogels with injectable, self-healing and antibacterial properties for wound healing.Carbohydr Polym. 2022 Jan 15;276:118718. doi: 10.1016/j.carbpol.2021.118718. Epub 2021 Oct 2. Carbohydr Polym. 2022. PMID: 34823762
-
Recent advances in polysaccharide-based self-healing hydrogels for biomedical applications.Carbohydr Polym. 2022 May 1;283:119161. doi: 10.1016/j.carbpol.2022.119161. Epub 2022 Jan 25. Carbohydr Polym. 2022. PMID: 35153030 Review.
-
Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review.Carbohydr Polym. 2018 Nov 1;199:445-460. doi: 10.1016/j.carbpol.2018.06.114. Epub 2018 Jun 28. Carbohydr Polym. 2018. PMID: 30143150 Review.
-
Multifunctional hydrogels for wound healing: Special focus on biomacromolecular based hydrogels.Int J Biol Macromol. 2021 Feb 15;170:728-750. doi: 10.1016/j.ijbiomac.2020.12.202. Epub 2020 Dec 30. Int J Biol Macromol. 2021. PMID: 33387543 Review.
-
Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing.Biomaterials. 2018 Nov;183:185-199. doi: 10.1016/j.biomaterials.2018.08.044. Epub 2018 Aug 24. Biomaterials. 2018. PMID: 30172244
Cited by
-
Recent Advances of Chitosan-Based Hydrogels for Skin-Wound Dressings.Gels. 2024 Feb 29;10(3):175. doi: 10.3390/gels10030175. Gels. 2024. PMID: 38534593 Free PMC article. Review.
-
Application of Chitosan-Based Hydrogel in Promoting Wound Healing: A Review.Polymers (Basel). 2024 Jan 26;16(3):344. doi: 10.3390/polym16030344. Polymers (Basel). 2024. PMID: 38337233 Free PMC article. Review.
-
Chitosan-based hydrogels: From preparation to applications, a review.Food Chem X. 2023 Dec 27;21:101095. doi: 10.1016/j.fochx.2023.101095. eCollection 2024 Mar 30. Food Chem X. 2023. PMID: 38268840 Free PMC article. Review.
-
Rapid Synthesis of Robust Antibacterial and Biodegradable Hydrogels via Frontal Polymerization.Gels. 2023 Nov 21;9(12):920. doi: 10.3390/gels9120920. Gels. 2023. PMID: 38131906 Free PMC article.
-
Chitosan-Based Self-Healing Hydrogel: From Fabrication to Biomedical Application.Polymers (Basel). 2023 Sep 14;15(18):3768. doi: 10.3390/polym15183768. Polymers (Basel). 2023. PMID: 37765622 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials