Molecular Imaging-Guided Sonodynamic Therapy

doi:10.1021/acs.bioconjchem.1c00288

Review

. 2022 Jun 15;33(6):993-1010.

doi: 10.1021/acs.bioconjchem.1c00288. Epub 2021 Oct 1.

Molecular Imaging-Guided Sonodynamic Therapy

Juan Guo¹, Xueting Pan¹, Chaohui Wang¹, Huiyu Liu¹

Affiliations

Affiliation

¹ Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, P.R. China.

PMID: 34595922
DOI: 10.1021/acs.bioconjchem.1c00288

Review

Molecular Imaging-Guided Sonodynamic Therapy

Juan Guo et al. Bioconjug Chem. 2022.

. 2022 Jun 15;33(6):993-1010.

doi: 10.1021/acs.bioconjchem.1c00288. Epub 2021 Oct 1.

Authors

Juan Guo¹, Xueting Pan¹, Chaohui Wang¹, Huiyu Liu¹

Affiliation

¹ Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, P.R. China.

PMID: 34595922
DOI: 10.1021/acs.bioconjchem.1c00288

Abstract

Low-intensity ultrasound-triggered sonodynamic therapy (SDT) is a promising noninvasive therapeutic modality due to its strong tissue penetration ability. In recent years, with the development of nanotechnology, nanoparticle-based sonosensitizer-mediated SDT has been widely investigated. With the increasing demand for precise and personalized treatment, abundant novel sonosensitizers with imaging capabilities have been developed for determining the optimal therapeutic window, thus significantly enhancing treatment efficacy. In this review, we focus on the molecular imaging-guided SDT. The prevalent mechanisms of SDT are discussed, including ultrasonic cavitation, sonoluminescence, reactive oxygen species, and mechanical damage. In addition, we introduce the major molecular imaging techniques and the design principles based on nanoparticles to achieve efficient imaging. Furthermore, the imaging-guided SDT for the treatment of cancer, bacterial infections, and vascular diseases is summarized. The ultimate goal is to design more effective imaging-guided SDT modalities and provide novel ideas for clinical translation of SDT.

PubMed Disclaimer

Cited by

Newly developed gas-assisted sonodynamic therapy in cancer treatment.
Pan M, Hu D, Yuan L, Yu Y, Li Y, Qian Z. Pan M, et al. Acta Pharm Sin B. 2023 Jul;13(7):2926-2954. doi: 10.1016/j.apsb.2022.12.021. Epub 2022 Dec 31. Acta Pharm Sin B. 2023. PMID: 37521874 Free PMC article. Review.
In-Situ Grown Nanocrystal TiO₂ on 2D Ti₃C₂ Nanosheets with Anti-Tumor Activity from Photo-Sonodynamic Treatment and Immunology.
Yu H, Huang Y, Nong Z, Lin X, Tang K, Cai Z, Huang K, Yu T, Lan H, Zhang Q, Wang Q, Yang L, Zhu J, Wu L, Luo H. Yu H, et al. Int J Nanomedicine. 2024 Aug 6;19:7963-7981. doi: 10.2147/IJN.S457112. eCollection 2024. Int J Nanomedicine. 2024. PMID: 39130689 Free PMC article.
Ferroptosis as a promising therapeutic strategy for melanoma.
Ta N, Jiang X, Zhang Y, Wang H. Ta N, et al. Front Pharmacol. 2023 Sep 19;14:1252567. doi: 10.3389/fphar.2023.1252567. eCollection 2023. Front Pharmacol. 2023. PMID: 37795022 Free PMC article. Review.
Recent Advances of ⁶⁸Ga-Labeled PET Radiotracers with Nitroimidazole in the Diagnosis of Hypoxia Tumors.
Nguyen AT, Kim HK. Nguyen AT, et al. Int J Mol Sci. 2023 Jun 23;24(13):10552. doi: 10.3390/ijms241310552. Int J Mol Sci. 2023. PMID: 37445730 Free PMC article. Review.
Recent Progress in Photothermal, Photodynamic and Sonodynamic Cancer Therapy: Through the cGAS-STING Pathway to Efficacy-Enhancing Strategies.
Fang K, Zhang H, Kong Q, Ma Y, Xiong T, Qin T, Li S, Zhu X. Fang K, et al. Molecules. 2024 Aug 5;29(15):3704. doi: 10.3390/molecules29153704. Molecules. 2024. PMID: 39125107 Free PMC article. Review.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- American Chemical Society

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Molecular Imaging-Guided Sonodynamic Therapy

Affiliation

Molecular Imaging-Guided Sonodynamic Therapy

Authors

Affiliation

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources