Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: US Preventive Services Task Force Recommendation Statement

doi:10.1001/jama.2021.14781

Practice Guideline

. 2021 Sep 28;326(12):1186-1191.

doi: 10.1001/jama.2021.14781.

Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: US Preventive Services Task Force Recommendation Statement

US Preventive Services Task Force; Karina W Davidson¹, Michael J Barry², Carol M Mangione³, Michael Cabana⁴, Aaron B Caughey⁵, Esa M Davis⁶, Katrina E Donahue⁷, Chyke A Doubeni⁸, Martha Kubik⁹, Li Li¹⁰, Gbenga Ogedegbe¹¹, Lori Pbert¹², Michael Silverstein¹³, Melissa A Simon¹⁴, James Stevermer¹⁵, Chien-Wen Tseng^{16

17}, John B Wong¹⁸

Affiliations

¹ Feinstein Institutes for Medical Research at Northwell Health, Manhasset, New York.
² Harvard Medical School, Boston, Massachusetts.
³ University of California, Los Angeles.
⁴ Albert Einstein College of Medicine, New York, New York.
⁵ Oregon Health & Science University, Portland.
⁶ University of Pittsburgh, Pittsburgh, Pennsylvania.
⁷ University of North Carolina at Chapel Hill.
⁸ Mayo Clinic, Rochester, Minnesota.
⁹ George Mason University, Fairfax, Virginia.
¹⁰ University of Virginia, Charlottesville.
¹¹ New York University, New York, New York.
¹² University of Massachusetts Medical School, Worcester.
¹³ Boston University, Boston, Massachusetts.
¹⁴ Northwestern University, Chicago, Illinois.
¹⁵ University of Missouri, Columbia.
¹⁶ University of Hawaii, Honolulu.
¹⁷ Pacific Health Research and Education Institute, Honolulu, Hawaii.
¹⁸ Tufts University School of Medicine, Boston, Massachusetts.

PMID: 34581729
DOI: 10.1001/jama.2021.14781

Practice Guideline

Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: US Preventive Services Task Force Recommendation Statement

US Preventive Services Task Force et al. JAMA. 2021.

. 2021 Sep 28;326(12):1186-1191.

doi: 10.1001/jama.2021.14781.

Authors

Affiliations

¹ Feinstein Institutes for Medical Research at Northwell Health, Manhasset, New York.
² Harvard Medical School, Boston, Massachusetts.
³ University of California, Los Angeles.
⁴ Albert Einstein College of Medicine, New York, New York.
⁵ Oregon Health & Science University, Portland.
⁶ University of Pittsburgh, Pittsburgh, Pennsylvania.
⁷ University of North Carolina at Chapel Hill.
⁸ Mayo Clinic, Rochester, Minnesota.
⁹ George Mason University, Fairfax, Virginia.
¹⁰ University of Virginia, Charlottesville.
¹¹ New York University, New York, New York.
¹² University of Massachusetts Medical School, Worcester.
¹³ Boston University, Boston, Massachusetts.
¹⁴ Northwestern University, Chicago, Illinois.
¹⁵ University of Missouri, Columbia.
¹⁶ University of Hawaii, Honolulu.
¹⁷ Pacific Health Research and Education Institute, Honolulu, Hawaii.
¹⁸ Tufts University School of Medicine, Boston, Massachusetts.

PMID: 34581729
DOI: 10.1001/jama.2021.14781

Abstract

Importance: Preeclampsia is one of the most serious health problems that affect pregnant persons. It is a complication in approximately 4% of pregnancies in the US and contributes to both maternal and infant morbidity and mortality. Preeclampsia also accounts for 6% of preterm births and 19% of medically indicated preterm births in the US. There are racial and ethnic disparities in the prevalence of and mortality from preeclampsia. Non-Hispanic Black women are at greater risk for developing preeclampsia than other women and experience higher rates of maternal and infant morbidity and perinatal mortality.

Objective: To update its 2014 recommendation, the USPSTF commissioned a systematic review to evaluate the effectiveness of low-dose aspirin use to prevent preeclampsia.

Population: Pregnant persons at high risk for preeclampsia who have no prior adverse effects with or contraindications to low-dose aspirin.

Evidence assessment: The USPSTF concludes with moderate certainty that there is a substantial net benefit of daily low-dose aspirin use to reduce the risk for preeclampsia, preterm birth, small for gestational age/intrauterine growth restriction, and perinatal mortality in pregnant persons at high risk for preeclampsia.

Recommendation: The USPSTF recommends the use of low-dose aspirin (81 mg/d) as preventive medication for preeclampsia after 12 weeks of gestation in persons who are at high risk for preeclampsia. (B recommendation).

PubMed Disclaimer

Comment in

Low-Dose Aspirin for the Prevention of Preeclampsia.
Espinoza J. Espinoza J. JAMA. 2021 Sep 28;326(12):1153-1155. doi: 10.1001/jama.2021.14646. JAMA. 2021. PMID: 34581753 No abstract available.

Summary for patients in

Use of Aspirin During Pregnancy to Prevent Preeclampsia.
Jin J. Jin J. JAMA. 2021 Sep 28;326(12):1222. doi: 10.1001/jama.2021.15900. JAMA. 2021. PMID: 34581735 No abstract available.

Cited by

Systematic design and evaluation of aptamers for VEGF and PlGF biomarkers of Preeclampsia.
Mallawarachchi S, Cebecioglu RE, Althumayri M, Beker L, Fernando S, Ceylan Koydemir H. Mallawarachchi S, et al. BMC Biotechnol. 2024 Sep 27;24(1):64. doi: 10.1186/s12896-024-00891-0. BMC Biotechnol. 2024. PMID: 39334133 Free PMC article.
The Impact of Sex and Gender on Stroke.
Rexrode KM, Madsen TE, Yu AYX, Carcel C, Lichtman JH, Miller EC. Rexrode KM, et al. Circ Res. 2022 Feb 18;130(4):512-528. doi: 10.1161/CIRCRESAHA.121.319915. Epub 2022 Feb 17. Circ Res. 2022. PMID: 35175851 Free PMC article. Review.
Preeclampsia: Recent Advances in Predicting, Preventing, and Managing the Maternal and Fetal Life-Threatening Condition.
Chang KJ, Seow KM, Chen KH. Chang KJ, et al. Int J Environ Res Public Health. 2023 Feb 8;20(4):2994. doi: 10.3390/ijerph20042994. Int J Environ Res Public Health. 2023. PMID: 36833689 Free PMC article. Review.
Energy metabolism and maternal-fetal tolerance working in decidualization.
Meng X, Chen C, Qian J, Cui L, Wang S. Meng X, et al. Front Immunol. 2023 Jun 19;14:1203719. doi: 10.3389/fimmu.2023.1203719. eCollection 2023. Front Immunol. 2023. PMID: 37404833 Free PMC article. Review.
Polygenic prediction of preeclampsia and gestational hypertension.
Honigberg MC, Truong B, Khan RR, Xiao B, Bhatta L, Vy HMT, Guerrero RF, Schuermans A, Selvaraj MS, Patel AP, Koyama S, Cho SMJ, Vellarikkal SK, Trinder M, Urbut SM, Gray KJ, Brumpton BM, Patil S, Zöllner S, Antopia MC, Saxena R, Nadkarni GN, Do R, Yan Q, Pe'er I, Verma SS, Gupta RM, Haas DM, Martin HC, van Heel DA, Laisk T, Natarajan P. Honigberg MC, et al. Nat Med. 2023 Jun;29(6):1540-1549. doi: 10.1038/s41591-023-02374-9. Epub 2023 May 29. Nat Med. 2023. PMID: 37248299 Free PMC article.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Silverchair Information Systems

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: US Preventive Services Task Force Recommendation Statement

Affiliations

Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: US Preventive Services Task Force Recommendation Statement

Authors

Affiliations

Abstract

Comment in

Summary for patients in

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Abstract

Comment in

Summary for patients in

Similar articles

Cited by

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources