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. 2021 Sep 16;10(9):1478.
doi: 10.3390/antiox10091478.

An Exploration of the Effects of an Early Postpartum Intravenous Infusion with Carnosic Acid on Physiological Responses of Transition Dairy Cows

Tainara Cristina Michelotti  1 , Erminio Trevisi  2 , Johan S Osorio  1
Affiliations

An Exploration of the Effects of an Early Postpartum Intravenous Infusion with Carnosic Acid on Physiological Responses of Transition Dairy Cows

Tainara Cristina Michelotti et al. Antioxidants (Basel). .

Abstract

The objective of the present study was to evaluate the effects of an antioxidant and anti-inflammatory compound found in rosemary plants (Salvia rosmarinus) named carnosic acid during the transition period of dairy cows. From day 1 to 3 after calving, 16 multiparous Holstein cows received a daily intravenous infusion of either 500 mL of saline (NaCl 0.9%; Saline; n = 8) or carnosic acid at a rate of 0.3 mg/kg of BW supplied in 500 mL of saline (CA; n = 8). Blood samples were taken at -7, 2, 5, 7, 14, and 21 d relative to parturition, then analyzed for metabolites related to energy metabolism, muscle mass catabolism, liver function, inflammation, and oxidative stress. CA infusion tended to improve milk performance; however, DMI was unaffected by treatment. At 2 d relative to parturition, CA cows had lower blood concentrations of haptoglobin, paraoxonase, FRAP, and NO2- than saline cows. After treatment infusions, haptoglobin remained lower in CA cows than saline at 5 d relative to parturition. Our results demonstrate that carnosic acid promoted positive responses on inflammation and oxidative stress biomarkers and may promote beneficial effects on lactation performance in peripartal dairy cows.

Keywords: carnosic acid; oxidative stress; peripartum.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Milk yield (A) and energy corrected milk (B) for peripartal dairy cows infused from 1 to 3 d postpartum with 500 mL of sterile saline solution (Saline) or carnosic acid (CA) at a rate of 0.3 mg/kg BW supplied in a total volume of 500 mL of sterile saline solution. Values are means, and the standard errors are represented by vertical bars.
Figure 2
Figure 2
Residual effects of carnosic acid (CA) or saline intravenous infusions on blood biomarkers from 5 to 21 d relative to parturition for haptoglobin. Mean separations between treatments at a given time point were evaluated at a treatment × time interaction (p ≤ 0.10), and differences (*) were declared at p ≤ 0.05. Values are means and the standard errors are represented by vertical bars.
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