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Review
. 2021 Sep 21;11(9):1390.
doi: 10.3390/biom11091390.

Cyclophilins and Their Functions in Abiotic Stress and Plant-Microbe Interactions

Przemysław Olejnik  1 , Cezary Jerzy Mądrzak  1 , Katarzyna Nuc  1
Affiliations
Review

Cyclophilins and Their Functions in Abiotic Stress and Plant-Microbe Interactions

Przemysław Olejnik et al. Biomolecules. .

Abstract

Plants have developed a variety of mechanisms and regulatory pathways to change their gene expression profiles in response to abiotic stress conditions and plant-microbe interactions. The plant-microbe interaction can be pathogenic or beneficial. Stress conditions, both abiotic and pathogenic, negatively affect the growth, development, yield and quality of plants, which is very important for crops. In contrast, the plant-microbe interaction could be growth-promoting. One of the proteins involved in plant response to stress conditions and plant-microbe interactions is cyclophilin. Cyclophilins (CyPs), together with FK506-binding proteins (FKBPs) and parvulins, belong to a big family of proteins with peptidyl-prolyl cis-trans isomerase activity (Enzyme Commission (EC) number 5.2.1.8). Genes coding for proteins with the CyP domain are widely expressed in all organisms examined, including bacteria, fungi, animals, and plants. Their different forms can be found in the cytoplasm, endoplasmic reticulum, nucleus, chloroplast, mitochondrion and in the phloem space. They are involved in numerous processes, such as protein folding, cellular signaling, mRNA processing, protein degradation and apoptosis. In the past few years, many new functions, and molecular mechanisms for cyclophilins have been discovered. In this review, we aim to summarize recent advances in cyclophilin research to improve our understanding of their biological functions in plant defense and symbiotic plant-microbe interactions.

Keywords: cyclophilins; pathogenesis; peptide bond isomerization; plant–microbe interaction; stress.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Fanghänel J., Fischer G. Insights into the Catalytic Mechanism of Peptidyl Prolyl Cis/Trans Isomerases. Front. Biosci. 2004;9:3453–3478. doi: 10.2741/1494. - DOI - PubMed
    1. Schiene C., Fischer G. Enzymes That Catalyse the Restructuring of Proteins. Curr. Opin. Struct. Biol. 2000;10:40–45. doi: 10.1016/S0959-440X(99)00046-9. - DOI - PubMed
    1. Romano P.G.N., Horton P., Gray J.E. The Arabidopsis Cyclophilin Gene Family. Plant. Physiol. 2004;134:1268–1282. doi: 10.1104/pp.103.022160. - DOI - PMC - PubMed
    1. Fischer G., Bang H., Mech C. Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides. Biomed. Biochim. Acta. 1984;43:1101–1111. - PubMed
    1. Cheng H.N., Bovey F.A. Cis-Trans Equilibrium and Kinetic Studies of Acetyl-L-Proline and Glycyl-L-Proline. Biopolymers. 1977;16:1465–1472. doi: 10.1002/bip.1977.360160707. - DOI - PubMed

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