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Review
. 2021 Sep 9:2021:6331630.
doi: 10.1155/2021/6331630. eCollection 2021.

Therapeutic Potential of Isoflavones with an Emphasis on Daidzein

Mohammed M Alshehri  1 , Javad Sharifi-Rad  2 , Jesús Herrera-Bravo  3   4 , Evelyn L Jara  3 , Luis A Salazar  4 , Dorota Kregiel  5 , Yadav Uprety  6 , Muhammad Akram  7 , Mehwish Iqbal  8 , Miquel Martorell  9 , Margalida Torrens-Mas  10 , Daniel Gabriel Pons  11 , Sevgi Durna Daştan  12   13 , Natália Cruz-Martins  14   15   16 , Fethi Ahmet Ozdemir  17 , Manoj Kumar  18 , William C Cho  19
Affiliations
Review

Therapeutic Potential of Isoflavones with an Emphasis on Daidzein

Mohammed M Alshehri et al. Oxid Med Cell Longev. .

Abstract

Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms to its potential anticancer and antiaging properties.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Chemical structure of daidzein.
Figure 2
Figure 2
Biotransformation of daidzein in human gut.
Figure 3
Figure 3
Various biological activities of the daidzein.
See this image and copyright information in PMC

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