The balance between NAD+ biosynthesis and consumption in ageing
- PMID: 34509469
- DOI: 10.1016/j.mad.2021.111569
The balance between NAD+ biosynthesis and consumption in ageing
Abstract
Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38. Cellular NAD+ levels regulate several essential processes including DNA repair, immune cell function, senescence, and chromatin remodelling. Maintenance of these cellular processes is important for healthy ageing and lifespan. Interestingly, the levels of NAD+ decline during ageing in several organisms, including humans. Declining NAD+ levels have been linked to several age-related diseases including various metabolic diseases and cognitive decline. Decreasing tissue NAD+ concentrations have been ascribed to an imbalance between biosynthesis and consumption of the dinucleotide, resulting from, for instance, reduced levels of the rate limiting enzyme NAMPT along with an increased activation state of the NAD+-consuming enzymes PARPs and CD38. The progression of some age-related diseases can be halted or reversed by therapeutic augmentation of NAD+ levels. NAD+ metabolism has therefore emerged as a potential target to ameliorate age-related diseases. The present review explores how ageing affects NAD+ metabolism and current approaches to reverse the age-dependent decline of NAD+.
Keywords: Ageing; NAD biosynthesis; NAD metabolism; PARP; Sirtuins.
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
Similar articles
-
NAD and the aging process: Role in life, death and everything in between.Mol Cell Endocrinol. 2017 Nov 5;455:62-74. doi: 10.1016/j.mce.2016.11.003. Epub 2016 Nov 5. Mol Cell Endocrinol. 2017. PMID: 27825999 Free PMC article. Review.
-
A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.Cell Metab. 2018 May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet.2018.03.016. Cell Metab. 2018. PMID: 29719225 Free PMC article.
-
NAD+ and sirtuins in aging and disease.Trends Cell Biol. 2014 Aug;24(8):464-71. doi: 10.1016/j.tcb.2014.04.002. Epub 2014 Apr 29. Trends Cell Biol. 2014. PMID: 24786309 Free PMC article. Review.
-
NAD+ metabolism and its roles in cellular processes during ageing.Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141. doi: 10.1038/s41580-020-00313-x. Epub 2020 Dec 22. Nat Rev Mol Cell Biol. 2021. PMID: 33353981 Free PMC article. Review.
-
NAD+-consuming enzymes in immune defense against viral infection.Biochem J. 2021 Dec 10;478(23):4071-4092. doi: 10.1042/BCJ20210181. Biochem J. 2021. PMID: 34871367 Free PMC article. Review.
Cited by
-
Elucidating the Role of Sirtuin 3 in Mammalian Oocyte Aging.Cells. 2024 Sep 22;13(18):1592. doi: 10.3390/cells13181592. Cells. 2024. PMID: 39329773 Free PMC article. Review.
-
Inhibition of UVB radiation-induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene.Photodermatol Photoimmunol Photomed. 2024 May;40(3):e12961. doi: 10.1111/phpp.12961. Photodermatol Photoimmunol Photomed. 2024. PMID: 38676310
-
Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID.NPJ Sci Food. 2024 Mar 30;8(1):19. doi: 10.1038/s41538-024-00261-2. NPJ Sci Food. 2024. PMID: 38555403 Free PMC article. Review.
-
The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation.Cells. 2024 Mar 21;13(6):550. doi: 10.3390/cells13060550. Cells. 2024. PMID: 38534394 Free PMC article. Review.
-
Reproductive Ageing: Current insights and a potential role of NAD in the reproductive health of aging fathers and their children.Reproduction. 2024 Apr 29;167(6):e230486. doi: 10.1530/REP-23-0486. Print 2024 Jun 1. Reproduction. 2024. PMID: 38471307 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous
