Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Nov;13(21):1907-1934.
doi: 10.4155/fmc-2021-0193. Epub 2021 Sep 1.

Medicinal applications of coumarins bearing azetidinone and thiazolidinone moieties

Affiliations
Review

Medicinal applications of coumarins bearing azetidinone and thiazolidinone moieties

Siddappa A Patil et al. Future Med Chem. 2021 Nov.

Abstract

Coumarins (2H-chromen-2-ones), also known as benzopyran-2-ones, are a family of naturally occurring heterocyclic ring systems that contain a lactone moiety. Coumarins exhibit a wide range of well-studied pharmacological properties. Over the last few decades, as a result of advances in diverse oriented synthetic routes, physicochemical properties and numerous biological activities, coumarins have become globally studied molecules from various synthetic and medicinal chemists. Recently, several bioactive coumarins bearing azetidinone and thiazolidinone moieties have been found to display a range of therapeutic characteristics, including antimicrobial, anticancer, antidiabetic and anti-inflammatory properties. This review offers a brief description of the synthetic methodologies, known bioactivity and structure-activity relationships of coumarins bearing azetidinones and thiazolidinones.

Keywords: anticancer; antimicrobial; antitubercular; antiviral; coumarin azetidinones; coumarin thiazolidinones.

PubMed Disclaimer

Similar articles

Cited by

MeSH terms

LinkOut - more resources