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Review
. 2021 Aug 11;10(8):1854.
doi: 10.3390/foods10081854.

Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases

Shuai Jiang  1 , Hui Liu  1 , Chunbao Li  1
Affiliations
Review

Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases

Shuai Jiang et al. Foods. .

Abstract

Oxidative stress is a status of imbalance between oxidants and antioxidants, resulting in molecular damage and interruption of redox signaling in an organism. Indeed, oxidative stress has been associated with many metabolic disorders due to unhealthy dietary patterns and may be alleviated by properly increasing the intake of antioxidants. Thus, it is quite important to adopt a healthy dietary mode to regulate oxidative stress and maintain cell and tissue homeostasis, preventing inflammation and chronic metabolic diseases. This review focuses on the links between dietary nutrients and health, summarizing the role of oxidative stress in 'unhealthy' metabolic pathway activities in individuals and how oxidative stress is further regulated by balanced diets.

Keywords: chronic metabolic inflammation; dietary mode; neurogenerative diseases; obesity; oxidative stress.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
ROS and oxidative stress. NOX, NADPH oxidase family; ROS, reactive oxygen species; NOS, nitric oxide synthase; SOD, superoxide dismutase; PRX, peroxiredoxin; CAT, catalase; GPX, glutathione peroxidase; H2O2, hydrogen peroxide; ·OH, hydroxide radicals.
Figure 2
Figure 2
Associations between diet and oxidative stress. ROS, reactive oxygen species; RNS, reactive nitrogen species; MDA, malondialdehyde; 4-HNE, 4-hydroxynonenal; NADPH, triphosphopyridine nucleotide; TNF-α, tumor necrosis factor alpha; IL-6, interleukin-6; IL-1β, interleukin-1β; CRP, C-reactive protein; NF-κB, nuclear factor kappa-B; Nrf2, NF-E2-related factor 2; ARE, antioxidant response element; p53, a tumor suppressor gene; K-ras, a proto-oncogene.
Figure 3
Figure 3
Associations between dietary patterns and physical exercise. SIRT-1, sirtuin1; MAPK, mitogen-activated protein kinase; BDNF, brain-derived neurotrophic factor; AIF, apoptosis inducing factor; Cyt c, Cytochrome C.
See this image and copyright information in PMC

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