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. 2021 Aug 4:2021:1058671.
doi: 10.1155/2021/1058671. eCollection 2021.

Efficacy of Oxidized Regenerated Cellulose/Collagen Dressing for Management of Skin Wounds: A Systematic Review and Meta-Analysis

Li Zhang  1 , Simei Wang  2 , Meihua Tan  2 , Hongwei Zhou  2 , Ying Tang  2 , Yan Zou  3
Affiliations

Efficacy of Oxidized Regenerated Cellulose/Collagen Dressing for Management of Skin Wounds: A Systematic Review and Meta-Analysis

Li Zhang et al. Evid Based Complement Alternat Med. .

Retraction in

Abstract

Objective: The purpose of this study was to evaluate the wound healing efficacy of oxidized regenerated cellulose (ORC)/collagen dressing and ORC/collagen/silver-ORC dressings compared to standard of care or control in treatment of chronic skin wounds such as diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), and pressure injuries sore ulcers (PISUs).

Methods: An electronic search was carried out in four popular databases PubMed, Scopus, Embase, and CENTRAL to identify thirteen included studies, comparing the clinical efficacy of ORC/collagen dressings when compared to control in management of chronic skin wounds, especially DFUs, VLUs, and PISUs, and skin graft donor site wounds.

Results: Consolidated data from thirteen comparative clinical studies undertaken for management of DFUs, VLUs, and PISUs showed favorable outcomes towards use of ORC/collagen compared to other traditional and hydrocolloid foam dressings in terms of wound healing rate (P=0.02) and percentage wound relative reduction (P=0.003). The time taken to achieve complete wound healing in the included studies did not show any statistical significant difference (P=0.24). There was no significant difference in adverse events between ORC/collagen-treated group and comparative group (P=0.19).

Conclusion: ORC/collagen wound dressings are beneficial in terms of improved wound healing rate and percentage wound relative reduction compared to already existing traditional standard of care with non-MMP, inhibiting biomaterials such as moistened gauze, autologous growth factors, hydrocolloid foam dressings, or ovine extracellular matrix.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flow chart showing study selection process.
Figure 2
Figure 2
Forest plot showing comparison of complete wound healing rate between ORC/collagen and control groups.
Figure 3
Figure 3
Forest plot showing comparison of time taken to achieve complete wound healing between ORC/collagen and control groups.
Figure 4
Figure 4
Forest plot showing comparison of percentage wound relative reduction between ORC/collagen and control groups.
Figure 5
Figure 5
Forest plot showing comparison of adverse events in wound healing between ORC/collagen and control groups.
Figure 6
Figure 6
Risk of (a) bias summary and (b) bias graph of all included studies.
See this image and copyright information in PMC

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