Alliances of the gut and bone axis
- PMID: 34303607
- DOI: 10.1016/j.semcdb.2021.06.024
Alliances of the gut and bone axis
Abstract
Gut hormones secreted from enteroendocrine cells following nutrient ingestion modulate metabolic processes including glucose homeostasis and food intake, and several of these gut hormones are involved in the regulation of the energy demanding process of bone remodelling. Here, we review the gut hormones considered or known to be involved in the gut-bone crosstalk and their role in orchestrating adaptions of bone formation and resorption as demonstrated in cellular and physiological experiments and clinical trials. Understanding the physiology and pathophysiology of the gut-bone axis may identify adverse effects of investigational drugs aimed to treat metabolic diseases such as type 2 diabetes and obesity and new therapeutic candidates for the treatment of bone diseases.
Keywords: Bone metabolism; Bone remodelling; Gut hormones; Gut-bone axis; Therapeutic targets.
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
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