Molecular mechanism involved in epithelial to mesenchymal transition
- PMID: 34252392
- DOI: 10.1016/j.abb.2021.108984
Molecular mechanism involved in epithelial to mesenchymal transition
Abstract
Epithelial to mesenchymal transition (EMT) is a biological process that plays an important role during embryonic development. During this process, the epithelial cells lose their polarity and acquire mesenchymal properties. In addition to embryonic development, EMT is also well-known to participate in tissue repair, inflammation, fibrosis, and tumor metastasis. In the present review, we address the basics of epithelial to mesenchymal transition during both development and disease conditions and emphasize the role of various transcription factors and miRNAs involved in the process.
Keywords: Cancer; Epithelial cells; Mesenchymal cells; miRNA.
Copyright © 2021 Elsevier Inc. All rights reserved.
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