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Review
. 2021 Jun 24;22(13):6771.
doi: 10.3390/ijms22136771.

2021 Update on Diagnostic Markers and Translocation in Salivary Gland Tumors

Malin Tordis Meyer  1 , Christoph Watermann  1 , Thomas Dreyer  2 , Süleyman Ergün  3 , Srikanth Karnati  3
Affiliations
Review

2021 Update on Diagnostic Markers and Translocation in Salivary Gland Tumors

Malin Tordis Meyer et al. Int J Mol Sci. .

Abstract

Salivary gland tumors are a rare tumor entity within malignant tumors of all tissues. The most common are malignant mucoepidermoid carcinoma, adenoid cystic carcinoma, and acinic cell carcinoma. Pleomorphic adenoma is the most recurrent form of benign salivary gland tumor. Due to their low incidence rates and complex histological patterns, they are difficult to diagnose accurately. Malignant tumors of the salivary glands are challenging in terms of differentiation because of their variability in histochemistry and translocations. Therefore, the primary goal of the study was to review the current literature to identify the recent developments in histochemical diagnostics and translocations for differentiating salivary gland tumors.

Keywords: adenoid cystic carcinoma (ACC); diagnostic markers; epithelial salivary gland; mucoepidermoid carcinoma; pleomorphic adenoma; salivary gland tumors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Comparison of the structural differences between control, pleomorphic adenoma (PMA), mucoepidermoid carcinoma (MEC), and acinar cell carcinoma (ACC) parotid gland tissue stained with HE staining. Control parotid tissue (A) is compared with PMA, which is composed of different cells of epithelial and mesenchymal lineage differentiations (B). ACC tumor cells resemble acinar cells in structure and pattern (C). MEC consists mostly of squamous epithelium and mucus-forming epithelium (D). Bars represent (A–D) 100 μm.
Figure 2
Figure 2
PMA marker reaction.
Figure 3
Figure 3
MEC marker reaction.
Figure 4
Figure 4
ADCC marker reaction.
Figure 5
Figure 5
ACC marker reaction.
See this image and copyright information in PMC

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