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Review
. 2021 Jun 7;11(6):753.
doi: 10.3390/brainsci11060753.

The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension

Polina V Moskaleva  1 , Natalya A Shnayder  1   2 , Marina M Petrova  1 , Daria S Kaskaeva  1 , Oksana A Gavrilyuk  1 , Sergey V Radostev  1 , Natalia P Garganeeva  3 , Victoria B Sharavii  4 , Elena E Vaiman  2 , Regina F Nasyrova  2
Affiliations
Review

The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension

Polina V Moskaleva et al. Brain Sci. .

Abstract

Migraine (M) and arterial hypertension (AH) are very common diseases. Today, there are a number of studies confirming and explaining their comorbidity. We searched PubMed, Springer, Scopus, Web of Science, Clinicalkeys, and Google Scholar databases for full-text English publications over the past 15 years using keywords and their combinations. The present review provides a synthesis of information about single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes involved in the development of M and essential AH. The results of studies we have discussed in this review are contradictory, which might be due to different designs of the studies, small sample sizes in some of them, as well as different social and geographical environments. Despite a high prevalence of the M and AH phenotype, its genetic markers have not yet been sufficiently studied. Specifically, there are separate molecular genetic studies aimed to identify SNVs of NOS1, NOS2, and NOS3 genes responsible for the development of M and those responsible for the development of AH. However, these SNVs have not been studied in patients with the phenotype of M and AH. In this review, we identify the SNVs that would be the most interesting to study in this aspect. Understanding the role of environmental factors and genetic predictors will contribute to a better diagnostics and exploration of new approaches to pathogenetic and disease-modifying treatment of the M and AH phenotype.

Keywords: NOS1; NOS2; NOS3; arterial hypertension; comorbidity; genes; migraine; nitric oxide; nitric oxide synthase; single nucleotide polymorphisms; single nucleotide variants.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Synthesis of nitric oxide.
Figure 2
Figure 2
The scheme of the migraine and arterial hypertension phenotype.
Figure 3
Figure 3
The scheme of the migraine and arterial hypertension phenotype: NI *—no or not enough information—SNVs’ studies on migraine versus AH are not available, but these SNVs may be potential markers of the phenotype in future studies.
See this image and copyright information in PMC

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