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Review
. 2021 Aug:146:103344.
doi: 10.1016/j.jri.2021.103344. Epub 2021 Jun 5.

Covid-19 pandemic: Perspectives on management

Premjith Gathiram  1 , Jagidesa Moodley  2 , Olive P Khaliq  2
Affiliations
Review

Covid-19 pandemic: Perspectives on management

Premjith Gathiram et al. J Reprod Immunol. 2021 Aug.

Abstract

The pandemic COVID-19 presents a major challenge to identify effective drugs for treatment. Clinicians need evidence based on randomized trials regarding effective medical treatments for this infection. Currently no effective therapies exist for the progression of the mild forms to severe disease. Knowledge however is rapidly expanding. Remdesivir, an anti- retroviral agent has in vitro activity against this virus and has shown to decrease the duration of ICU care in patients with severe disease, while low dose dexamethasone also showed a decrease in the duration of stay in cases of severe disease requiring assisted ventilation. At the time of writing this article, two mRNA-based vaccines have shown an approximate 95 % efficacy in preventing infection in large clinical trials. At least one of these drugs has regulatory permission for vaccination in high-income countries. Low and middle-income countries may have difficulties in initiating vaccine programs on large scales because of availability, costs, refrigeration and dissemination. Adequately powered randomized trials are required for drugs with in vitro activity against the virus. Supportive care should be provided for stable, hypoxia and pneumonia free patients on imaging. Vaccines are of obvious benefit and given the preliminary evidence of the efficacy of over 95 %, Low and middle-income countries must develop links with the WHO COVAX program to ensure global distribution of vaccines.

Keywords: ACE inhibitors; Angiotensin receptor blockers; COVID-19 vaccines; SARS-COV-2.

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Conflict of interest statement

The authors report no declarations of interest.

Figures

Fig. 1
Fig. 1
Action of ACE-2 and ACE on the formation of ANG-(1-7) from ANG I and ANG II (Adopted from (Aronson and Ferner, 2020).
See this image and copyright information in PMC

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