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Multicenter Study
. 2021 Jun 17;11(1):12753.
doi: 10.1038/s41598-021-92090-6.

DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma

Guillaume B Cardin  1   2 , Monique Bernard  1   2 , Francis Rodier  1   2   3 , Apostolos Christopoulos  4   5   6
Affiliations
Multicenter Study

DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma

Guillaume B Cardin et al. Sci Rep. .

Abstract

Germline single nucleotide polymorphisms in the promoter region of the DCBLD1 gene are associated with non-smoking cases of both non-small cell lung carcinoma (NSCLC) and human papillomavirus-negative head and neck cancer. However the clinical relevance and function of DCBLD1 remain unclear. This multicenter retrospective study was designed to evaluate the prognostic value and function of DCBLD1 in the four main solid cancers: NSCLC, invasive breast carcinoma, colorectal adenocarcinoma and prostate adenocarcinoma. We included the following cohorts: GSE81089 NSCLC, METABRIC invasive breast carcinoma, GSE14333 colorectal adenocarcinoma, GSE70770 prostate adenocarcinoma and The Cancer Genome Atlas (TCGA) Firehose Legacy cohorts of all four cancers. DCBLD1 gene expression was associated with a worse overall survival in multivariate analyses for both NSCLC cohorts (TCGA: P = 0.03 and GSE81089: P = 0.04) and both invasive breast carcinoma cohorts (TCGA: P = 0.02 and METABRIC: P < 0.001). Patients with high DCBLD1 expression showed an upregulation of the integrin signaling pathway in comparison to those with low DCBLD1 expression in the TCGA NSCLC cohort (FDR = 5.16 × 10-14) and TCGA invasive breast carcinoma cohort (FDR = 1.94 × 10-05).

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
DCBLD1 in the TCGA and GSE81089 cohorts of non-small cell lung carcinoma. Comparison of DCBLD1 gene expression for age (A, B), sex (C, D), stage (E, F), tobacco use (G, H) and histology (I, J).
Figure 2
Figure 2
DCBLD1 in the TCGA and METABRIC cohorts of invasive breast cancer. Comparison of DCBLD1 gene expression for PAM50 subtypes (A, B), age (C, D) and stage (E, F).
Figure 3
Figure 3
Evaluation of DCBLD1 expression in tumor tissue. Comparison of DCBLD1 gene expression in normal tissue adjacent to the tumor and tumor tissue for NSCLC (A), invasive breast carcinoma (B), colorectal adenocarcinoma (C) and prostate adenocarcinoma (D) TCGA cohorts.
Figure 4
Figure 4
Differentially expressed genes in patients with high DCBLD1 expression NSCLC, invasive breast carcinoma and HNSCC. STRING protein interaction analysis of the 37 genes differentially regulated for patients with high DCBLD1 expression (n = 50) in comparison to those with low DCBLD1 expression (n = 50) in the TCGA cohorts for NSCLC, invasive breast carcinoma and HNSCC TCGA cohorts. The network shows results for the highest confidence interval (0.9) interaction scores on STRING v11 (https://string-db.org/). STRBP has lower expression, while the 36 other genes have higher expression in patients with high DCBLD1 expression.
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