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Review
. 2021 May 26;13(5):366-385.
doi: 10.4252/wjsc.v13.i5.366.

Stem cell therapy in ocular pathologies in the past 20 years

Giovanni Miotti  1 , Pier Camillo Parodi  1 , Marco Zeppieri  2
Affiliations
Review

Stem cell therapy in ocular pathologies in the past 20 years

Giovanni Miotti et al. World J Stem Cells. .

Abstract

Stem cell therapies are successfully used in various fields of medicine. This new approach of research is also expanding in ophthalmology. Huge investments, resources and important clinical trials have been performed in stem cell research and in potential therapies. In recent years, great strides have been made in genetic research, which permitted and enhanced the differentiation of stem cells. Moreover, the possibility of exploiting stem cells from other districts (such as adipose, dental pulp, bone marrow stem cells, etc.) for the treatment of ophthalmic diseases, renders this topic fascinating. Furthermore, great strides have been made in biomedical engineering, which have proposed new materials and three-dimensional structures useful for cell therapy of the eye. The encouraging results obtained on clinical trials conducted on animals have given a significant boost in the creation of study protocols also in humans. Results are limited to date, but clinical trials continue to evolve. Our attention is centered on the literature reported over the past 20 years, considering animal (the most represented in literature) and human clinical trials, which are limiting. The aim of our review is to present a brief overview of the main types of treatments based on stem cells in the field of ophthalmic pathologies.

Keywords: Adipose stem cells; Cell therapies; Cornea; Eye pathology; Multipotent mesenchymal cells; New materials; Novel therapies; Stem cells.

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Conflict of interest statement

Conflict-of-interest statement: Authors declare no conflict of interests for this article.

Figures

Figure 1
Figure 1
The selection of PubMed literature published from 2000 to 2020, which was considered in the manuscript.
See this image and copyright information in PMC

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