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Review
. 2021 May 21:11:632256.
doi: 10.3389/fonc.2021.632256. eCollection 2021.

Beyond Conventional: The New Horizon of Targeted Therapy for the Treatment of Advanced Non Small Cell Lung Cancer

Alfredo Tartarone  1 , Vittoria Lapadula  1 , Concetta Di Micco  2 , Gemma Rossi  3 , Carlotta Ottanelli  3 , Andrea Marini  3 , Roberta Giorgione  3 , Katia Ferrari  4 , Martina Catalano  3 , Luca Voltolini  5 , Enrico Mini  6 , Giandomenico Roviello  6
Affiliations
Review

Beyond Conventional: The New Horizon of Targeted Therapy for the Treatment of Advanced Non Small Cell Lung Cancer

Alfredo Tartarone et al. Front Oncol. .

Abstract

In the last few years the advent of targeted therapies against oncogenic drivers significantly improved the survival of non small cell lung cancer (NSCLC) patients with a favourable toxicity profile. Therefore, genetic testing, including at least EGFR mutations and ALK/ROS1 rearrangements, should be performed in all NSCLC patients (in particular with adenocarcinoma) who received a diagnosis of advanced disease. This review focuses on novel druggable oncogenic drivers, such as MET exon 14 mutations/MET amplification, RET fusions, BRAF V600E mutations, KRAS G12C mutations, NTRK rearrangements, and HER2 alterations.

Keywords: MET; genetic testing; non small cell lung cancer; oncogenic drivers; targeted therapies.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Novel druggable oncogenic drivers in NSCLC.
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