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Review
. 2021 May 21;9(2):32.
doi: 10.3390/medsci9020032.

The Mechanisms for the Association of Cancer and Esophageal Dysmotility Disorders

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Review

The Mechanisms for the Association of Cancer and Esophageal Dysmotility Disorders

Francisco Tustumi et al. Med Sci (Basel). .

Abstract

Background: Achalasia and other esophageal dysmotility disorders mimicking achalasia can be associated with cancer. This study aimed to review the main mechanisms for which cancer may develop in esophageal dysmotility disorder patients.

Methods: A narrative review was performed.

Results: The mechanism for developing squamous cell carcinoma and adenocarcinoma are discussed. Besides, achalasia-like syndromes related to familial KIT-gene mutation and pseudoachalasia are discussed.

Conclusions: Knowing the main mechanism for which achalasia can be related to cancer is essential for clinicians to conduct the proper investigation, surveillance, and treatment.

Keywords: achalasia; carcinoma; esophagus; neoplasm; squamous cell carcinoma.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The main mechanisms for DNA damage and cancer development in achalasia.

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