Translational biomarkers in the era of precision medicine

doi:10.1016/bs.acc.2020.08.002

Review

. 2021:102:191-232.

doi: 10.1016/bs.acc.2020.08.002. Epub 2020 Oct 3.

Translational biomarkers in the era of precision medicine

Laura Bravo-Merodio¹, Animesh Acharjee², Dominic Russ¹, Vartika Bisht¹, John A Williams³, Loukia G Tsaprouni⁴, Georgios V Gkoutos⁵

Affiliations

¹ Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom; Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom.
² Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom; Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom; NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospital Birmingham, Birmingham, United Kingdom. Electronic address: a.acharjee@bham.ac.uk.
³ Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom; Medical Research Council Harwell Institute, Harwell Campus, Oxfordshire, United Kingdom.
⁴ Birmingham City University, Centre for Life and Sport Science, Birmingham, United Kingdom.
⁵ Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom; Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom; NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospital Birmingham, Birmingham, United Kingdom; MRC Health Data Research UK (HDR UK), London, United Kingdom; NIHR Experimental Cancer Medicine Centre, Birmingham, United Kingdom; NIHR Biomedical Research Centre, University Hospital Birmingham, Birmingham, United Kingdom.

PMID: 34044910
DOI: 10.1016/bs.acc.2020.08.002

Review

Translational biomarkers in the era of precision medicine

Laura Bravo-Merodio et al. Adv Clin Chem. 2021.

. 2021:102:191-232.

doi: 10.1016/bs.acc.2020.08.002. Epub 2020 Oct 3.

Authors

Laura Bravo-Merodio¹, Animesh Acharjee², Dominic Russ¹, Vartika Bisht¹, John A Williams³, Loukia G Tsaprouni⁴, Georgios V Gkoutos⁵

Affiliations

¹ Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom; Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom.
² Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom; Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom; NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospital Birmingham, Birmingham, United Kingdom. Electronic address: a.acharjee@bham.ac.uk.
³ Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom; Medical Research Council Harwell Institute, Harwell Campus, Oxfordshire, United Kingdom.
⁴ Birmingham City University, Centre for Life and Sport Science, Birmingham, United Kingdom.
⁵ Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom; Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom; NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospital Birmingham, Birmingham, United Kingdom; MRC Health Data Research UK (HDR UK), London, United Kingdom; NIHR Experimental Cancer Medicine Centre, Birmingham, United Kingdom; NIHR Biomedical Research Centre, University Hospital Birmingham, Birmingham, United Kingdom.

PMID: 34044910
DOI: 10.1016/bs.acc.2020.08.002

Abstract

In this chapter we discuss the past, present and future of clinical biomarker development. We explore the advent of new technologies, paving the way in which health, medicine and disease is understood. This review includes the identification of physicochemical assays, current regulations, the development and reproducibility of clinical trials, as well as, the revolution of omics technologies and state-of-the-art integration and analysis approaches.

Keywords: Artificial intelligence; Big data; Clinical trials; Omics; Translational biomarkers.

PubMed Disclaimer

Cited by

Taurine as a biomarker for aging: A new avenue for translational research.
Acharjee A. Acharjee A. Adv Biomark Sci Technol. 2023;5:86-88. doi: 10.1016/j.abst.2023.10.002. Adv Biomark Sci Technol. 2023. PMID: 38435677 Free PMC article. Review.
Unlocking protein-based biomarker potential for graft-versus-host disease following allogenic hematopoietic stem cell transplants.
Iacobescu M, Pop C, Uifălean A, Mogoşan C, Cenariu D, Zdrenghea M, Tănase A, Bergthorsson JT, Greiff V, Cenariu M, Iuga CA, Tomuleasa C, Tătaru D. Iacobescu M, et al. Front Immunol. 2024 Feb 16;15:1327035. doi: 10.3389/fimmu.2024.1327035. eCollection 2024. Front Immunol. 2024. PMID: 38433830 Free PMC article. Review.
The cancer glycocode as a family of diagnostic biomarkers, exemplified by tumor-associated gangliosides.
Nejatie A, Yee SS, Jeter A, Saragovi HU. Nejatie A, et al. Front Oncol. 2023 Oct 26;13:1261090. doi: 10.3389/fonc.2023.1261090. eCollection 2023. Front Oncol. 2023. PMID: 37954075 Free PMC article. Review.
Editorial: Integrative multi-modal, multi-omics analytics for the better understanding of metabolic diseases.
Acharjee A, Agarwal P, Gkoutos GV. Acharjee A, et al. Front Endocrinol (Lausanne). 2023 Sep 8;14:1266557. doi: 10.3389/fendo.2023.1266557. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37745706 Free PMC article. No abstract available.
DNA-Methylation Signatures of Tobacco Smoking in a High Cardiovascular Risk Population: Modulation by the Mediterranean Diet.
Fernández-Carrión R, Sorlí JV, Asensio EM, Pascual EC, Portolés O, Alvarez-Sala A, Francès F, Ramírez-Sabio JB, Pérez-Fidalgo A, Villamil LV, Tinahones FJ, Estruch R, Ordovas JM, Coltell O, Corella D. Fernández-Carrión R, et al. Int J Environ Res Public Health. 2023 Feb 18;20(4):3635. doi: 10.3390/ijerph20043635. Int J Environ Res Public Health. 2023. PMID: 36834337 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
Other Literature Sources
- The Lens - Patent Citations
- scite Smart Citations
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Translational biomarkers in the era of precision medicine

Affiliations

Translational biomarkers in the era of precision medicine

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Miscellaneous

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources

Miscellaneous