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Case Reports
. 2021 May 4:11:664475.
doi: 10.3389/fonc.2021.664475. eCollection 2021.

Case Report: Various Abnormalities in Lipid and Glucose Metabolism Induced by Capecitabine

Takatoshi Anno  1 , Tomoki Yamatsuji  2 , Koichi Tomoda  1 , Shuhei Nakanishi  3 , Hideaki Kaneto  3
Affiliations
Case Reports

Case Report: Various Abnormalities in Lipid and Glucose Metabolism Induced by Capecitabine

Takatoshi Anno et al. Front Oncol. .

Abstract

Capecitabine has been used for the treatment of various types of tumors. The rare side effects induced by capecitabine have been reported as hypertriglyceridemia, acute pancreatitis associated with hypertriglyceridemia and hypertriglyceridemia complicated with hyperglycemia. The mechanisms of capecitabine-induced hypertriglyceridemia are unclear. In this report, we present a subject with sigmoid colon cancer and capecitabine-induced dyslipidemia. LDL-cholesterol level was markedly elevated throughout the long period of treatment with capecitabine. In addition, triglyceride level was high and not stable during the treatment period. Her dyslipidemia was ameliorated by the treatment with 5 mg of rosuvastatin, which is one of the HMG-CoA reductase inhibitors.

Keywords: capecitabine; dyslipidemia; hypercholesterolemia; hyperinsulinemia; hypertriglyceridemia; metabolic disorder.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Clinical time course of clinical parameters in this subject. After emergency surgery, this patient underwent 6 courses of chemotherapy including capecitabine. After emergency surgery, she was treated with 500 mg of metformin for diabetes mellitus. In addition, through the chemotherapy including capecitabine, her plasma insulin level and LDL-cholesterol level were markedly elevated. And then, she was treated with 5 mg of rosuvastatin, one of the HMG-CoA reductases, for the treatment of dyslipidemia. Her plasma insulin and LDL-cholesterol level were markedly decreased.
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