Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation
- PMID: 33985920
- DOI: 10.1016/j.molmed.2021.04.006
Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation
Abstract
Cellular function is shaped by transcriptional and post-transcriptional mechanisms, including alternative polyadenylation (APA). By directly controlling 3'- untranslated region (UTR) length and the selection of the last exon, APA regulates up to 70% of all cellular transcripts influencing RNA stability, output, and protein isoform expression. Cell-state-dependent 3'-UTR shortening has been identified as a hallmark of cellular proliferation. Hence, quiescent/dormant stem cells are characterized by long 3'-UTRs, whereas proliferative stem/progenitor cells exhibit 3'-UTR shortening. Here, the latest studies analyzing the role of APA in regulating stem cell state, self-renewal, differentiation, and metabolism are reviewed. The new role of APA in controlling stem cell fate opens novel potential therapeutic avenues in the field of regenerative medicine.
Keywords: alternative polyadenylation; cell cycle; self-renewal; stem cells.
Copyright © 2021. Published by Elsevier Ltd.
Conflict of interest statement
Declaration of Interests The authors declare no competing interests.
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