Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review

doi:10.1186/s13578-021-00602-8

Review

. 2021 May 13;11(1):86.

doi: 10.1186/s13578-021-00602-8.

Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review

Qun Chen^#^{1

2}, Wu-Jun Wang^#³, Yun-Xuan Jia^#², Hao Yuan^#^{1

2}, Peng-Fei Wu^{1

2}, Wan-Li Ge^{1

2}, Ling-Dong Meng^{1

2}, Xu-Min Huang^{1

2}, Peng Shen^{1

2}, Tao-Yue Yang^{1

2}, Yi Miao^{1

2}, Jing-Jing Zhang^{4

5}, Kui-Rong Jiang^{6

7}

Affiliations

¹ Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China.
² Nanjing Medical University, Nanjing, China.
³ Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
⁴ Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China. zhangjingjing@njmu.edu.cn.
⁵ Nanjing Medical University, Nanjing, China. zhangjingjing@njmu.edu.cn.
⁶ Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China. jiangkuirong@njmu.edu.cn.
⁷ Nanjing Medical University, Nanjing, China. jiangkuirong@njmu.edu.cn.

^# Contributed equally.

PMID: 33985581
PMCID: PMC8120816
DOI: 10.1186/s13578-021-00602-8

Review

Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review

Qun Chen et al. Cell Biosci. 2021.

. 2021 May 13;11(1):86.

doi: 10.1186/s13578-021-00602-8.

Authors

Affiliations

¹ Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China.
² Nanjing Medical University, Nanjing, China.
³ Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
⁴ Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China. zhangjingjing@njmu.edu.cn.
⁵ Nanjing Medical University, Nanjing, China. zhangjingjing@njmu.edu.cn.
⁶ Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China. jiangkuirong@njmu.edu.cn.
⁷ Nanjing Medical University, Nanjing, China. jiangkuirong@njmu.edu.cn.

^# Contributed equally.

PMID: 33985581
PMCID: PMC8120816
DOI: 10.1186/s13578-021-00602-8

Abstract

Pancreatic tumors are classified into endocrine and exocrine types, and the clinical manifestations in patients are nonspecific. Most patients, especially those with pancreatic ductal adenocarcinoma (PDAC), have lost the opportunity to receive for the best treatment at the time of diagnosis. Although chemotherapy and radiotherapy have shown good therapeutic results in other tumors, their therapeutic effects on pancreatic tumors are minimal. A multifunctional transcription factor, Yin-Yang 1 (YY1) regulates the transcription of a variety of important genes and plays a significant role in diverse tumors. Studies have shown that targeting YY1 can improve the survival time of patients with tumors. In this review, we focused on the mechanism by which YY1 affects the occurrence and development of pancreatic tumors. We found that a YY1 mutation is specific for insulinomas and has a role in driving the degree of malignancy. In addition, changes in the circadian network are a key causative factor of PDAC. YY1 promotes pancreatic clock progression and induces malignant changes, but YY1 seems to act as a tumor suppressor in PDAC and affects many biological behaviors, such as proliferation, migration, apoptosis and metastasis. Our review summarizes the progress in understanding the role of YY1 in pancreatic endocrine and exocrine tumors and provides a reasonable assessment of the potential for therapeutic targeting of YY1 in pancreatic tumors.

Keywords: Mutation; Pancreatic ductal adenocarcinoma; Pancreatic neuroendocrine tumor; Tumor suppressor; YY1.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

**Fig. 1**
Relationships between YY1 and PDAC

See this image and copyright information in PMC

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References

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[1] Zhou Q, Melton DA. Pancreas regeneration. Nature. 2018;557(7705):351–358. doi: 10.1038/s41586-018-0088-0. - DOI - PMC - PubMed

[2] Zhou Q, Melton DA. Pancreas regeneration. Nature. 2018;557(7705):351–358. doi: 10.1038/s41586-018-0088-0. - DOI - PMC - PubMed

[3] Shih HP, Wang A, Sander M. Pancreas organogenesis: from lineage determination to morphogenesis. Annu Rev Cell Dev Biol. 2013;29:81–105. doi: 10.1146/annurev-cellbio-101512-122405. - DOI - PubMed

[4] Shih HP, Wang A, Sander M. Pancreas organogenesis: from lineage determination to morphogenesis. Annu Rev Cell Dev Biol. 2013;29:81–105. doi: 10.1146/annurev-cellbio-101512-122405. - DOI - PubMed

[5] Tehrani Z, Lin S. Endocrine pancreas development in zebrafish. Cell Cycle. 2011;10(20):3466–3472. doi: 10.4161/cc.10.20.17764. - DOI - PubMed

[6] Tehrani Z, Lin S. Endocrine pancreas development in zebrafish. Cell Cycle. 2011;10(20):3466–3472. doi: 10.4161/cc.10.20.17764. - DOI - PubMed

[7] Dubois PM. Ontogeny of the endocrine pancreas. Horm Res. 1989;32(1–3):53–60. doi: 10.1159/000181245. - DOI - PubMed

[8] Dubois PM. Ontogeny of the endocrine pancreas. Horm Res. 1989;32(1–3):53–60. doi: 10.1159/000181245. - DOI - PubMed

[9] Henry BM, Skinningsrud B, Saganiak K, Pękala PA, Walocha JA, Tomaszewski KA. Development of the human pancreas and its vasculature - an integrated review covering anatomical, embryological, histological, and molecular aspects. Ann Anat. 2019;221:115–124. doi: 10.1016/j.aanat.2018.09.008. - DOI - PubMed

[10] Henry BM, Skinningsrud B, Saganiak K, Pękala PA, Walocha JA, Tomaszewski KA. Development of the human pancreas and its vasculature - an integrated review covering anatomical, embryological, histological, and molecular aspects. Ann Anat. 2019;221:115–124. doi: 10.1016/j.aanat.2018.09.008. - DOI - PubMed

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Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review

Affiliations

Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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Cited by

References

Publication types

Grants and funding

LinkOut - more resources

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