Biogenesis, cellular effects, and biomarker value of circHIPK3

doi:10.1186/s12935-021-01956-2

Review

. 2021 May 11;21(1):256.

doi: 10.1186/s12935-021-01956-2.

Biogenesis, cellular effects, and biomarker value of circHIPK3

Yihan Fu^{1

2}, Hong Sun³

Affiliations

¹ Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
² Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China.
³ Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China. hongsun57@hotmail.com.

PMID: 33975598
PMCID: PMC8111742
DOI: 10.1186/s12935-021-01956-2

Review

Biogenesis, cellular effects, and biomarker value of circHIPK3

Yihan Fu et al. Cancer Cell Int. 2021.

. 2021 May 11;21(1):256.

doi: 10.1186/s12935-021-01956-2.

Authors

Yihan Fu^{1

2}, Hong Sun³

Affiliations

¹ Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
² Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China.
³ Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China. hongsun57@hotmail.com.

PMID: 33975598
PMCID: PMC8111742
DOI: 10.1186/s12935-021-01956-2

Abstract

Competing endogenous RNAs (ceRNAs) can indirectly regulate gene expression by competitively binding to microRNA(miRNA) through miRNA response elements (MREs) to affect miRNA-induced gene regulation, which is of great biological significance. Among them, circular RNA (circRNA) has become a hotspot due to its highest binding capacity. A specific circRNA discussed in this review, circHIPK3, has been studied for its biological characteristics, function, cellular effects and its relationship with tumors and various diseases. Here, we review the recent researches about circHIPK3 in detail and aim to elucidate accurate conclusions from them. These circHIPK3-miRNAs-mRNA pathways will further advance the application of circHIPK3 in diseases development, early diagnosis and gene targeting therapy.

Keywords: Biomarker; Cancer; CircHIPK3; MiRNAs sponge.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

**Fig. 1**
Biogenesis and formation of circHIPK3

**Fig. 2**
Overview of circHIPK-sponged miRNAs and their targeted genes

See this image and copyright information in PMC

Cited by

Regulation of the Key Epithelial Cancer Suppressor miR-124 Function by Competing Endogenous RNAs.
Braga EA, Fridman MV, Burdennyy AM, Filippova EA, Loginov VI, Pronina IV, Dmitriev AA, Kushlinskii NE. Braga EA, et al. Int J Mol Sci. 2022 Nov 7;23(21):13620. doi: 10.3390/ijms232113620. Int J Mol Sci. 2022. PMID: 36362406 Free PMC article. Review.
Noncoding RNAs: Master Regulator of Fibroblast to Myofibroblast Transition in Fibrosis.
Zhang H, Zhou Y, Wen D, Wang J. Zhang H, et al. Int J Mol Sci. 2023 Jan 16;24(2):1801. doi: 10.3390/ijms24021801. Int J Mol Sci. 2023. PMID: 36675315 Free PMC article. Review.
Functions of Circular RNA in Human Diseases and Illnesses.
Gu A, Jaijyan DK, Yang S, Zeng M, Pei S, Zhu H. Gu A, et al. Noncoding RNA. 2023 Jul 4;9(4):38. doi: 10.3390/ncrna9040038. Noncoding RNA. 2023. PMID: 37489458 Free PMC article. Review.
The potential of circHIPK3 as a biomarker in chronic myeloid leukemia.
Gomez EW, De Paula LB, Weimer RD, Hellwig AHDS, Rodrigues GM, Alegretti AP, de Oliveira JR. Gomez EW, et al. Front Oncol. 2024 Mar 5;14:1330592. doi: 10.3389/fonc.2024.1330592. eCollection 2024. Front Oncol. 2024. PMID: 38505596 Free PMC article. Review.
Exosome-delivered circSATB2 targets the miR-330-5p/PEAK1 axis to regulate proliferation, migration and invasion of lung cancer cells.
Zhu J, Wang F, Weng Y, Zhao J. Zhu J, et al. Thorac Cancer. 2022 Nov;13(21):3007-3017. doi: 10.1111/1759-7714.14652. Epub 2022 Sep 23. Thorac Cancer. 2022. PMID: 36148757 Free PMC article.

See all "Cited by" articles

References

1. Anderson CM, Macleod KF. Autophagy and cancer cell metabolism. Int Rev Cell Mol Biol. 2019;347:145–190. doi: 10.1016/bs.ircmb.2019.06.002. - DOI - PMC - PubMed
1. Bai M, Pan CL, Jiang GX, Zhang YM, Zhang Z. CircHIPK3 aggravates myocardial ischemia-reperfusion injury by binding to miRNA-124-3p. Eur Rev Med Pharmacol Sci. 2019;23(22):10107–10114. doi: 10.26355/eurrev_201911_19580. - DOI - PubMed
1. Bergsbaken T, Fink SL, Cookson BT. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol. 2009;7(2):99–109. doi: 10.1038/nrmicro2070. - DOI - PMC - PubMed
1. Bi L, Zhang C, Yao Y, He Z. Circ-HIPK3 regulates YAP1 expression by sponging miR-381–3p to promote oral squamous cell carcinoma development. J Biosci. 2021:46. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/33737493. - PubMed
1. Bolha L, Ravnik-Glavac M, Glavac D. Circular RNAs: biogenesis, function, and a role as possible cancer biomarkers. Int J Genomics. 2017;2017:6218353. doi: 10.1155/2017/6218353. - DOI - PMC - PubMed

Publication types

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

[1] Anderson CM, Macleod KF. Autophagy and cancer cell metabolism. Int Rev Cell Mol Biol. 2019;347:145–190. doi: 10.1016/bs.ircmb.2019.06.002. - DOI - PMC - PubMed

[2] Anderson CM, Macleod KF. Autophagy and cancer cell metabolism. Int Rev Cell Mol Biol. 2019;347:145–190. doi: 10.1016/bs.ircmb.2019.06.002. - DOI - PMC - PubMed

[3] Bai M, Pan CL, Jiang GX, Zhang YM, Zhang Z. CircHIPK3 aggravates myocardial ischemia-reperfusion injury by binding to miRNA-124-3p. Eur Rev Med Pharmacol Sci. 2019;23(22):10107–10114. doi: 10.26355/eurrev_201911_19580. - DOI - PubMed

[4] Bai M, Pan CL, Jiang GX, Zhang YM, Zhang Z. CircHIPK3 aggravates myocardial ischemia-reperfusion injury by binding to miRNA-124-3p. Eur Rev Med Pharmacol Sci. 2019;23(22):10107–10114. doi: 10.26355/eurrev_201911_19580. - DOI - PubMed

[5] Bergsbaken T, Fink SL, Cookson BT. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol. 2009;7(2):99–109. doi: 10.1038/nrmicro2070. - DOI - PMC - PubMed

[6] Bergsbaken T, Fink SL, Cookson BT. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol. 2009;7(2):99–109. doi: 10.1038/nrmicro2070. - DOI - PMC - PubMed

[7] Bi L, Zhang C, Yao Y, He Z. Circ-HIPK3 regulates YAP1 expression by sponging miR-381–3p to promote oral squamous cell carcinoma development. J Biosci. 2021:46. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/33737493. - PubMed

[8] Bi L, Zhang C, Yao Y, He Z. Circ-HIPK3 regulates YAP1 expression by sponging miR-381–3p to promote oral squamous cell carcinoma development. J Biosci. 2021:46. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/33737493. - PubMed

[9] Bolha L, Ravnik-Glavac M, Glavac D. Circular RNAs: biogenesis, function, and a role as possible cancer biomarkers. Int J Genomics. 2017;2017:6218353. doi: 10.1155/2017/6218353. - DOI - PMC - PubMed

[10] Bolha L, Ravnik-Glavac M, Glavac D. Circular RNAs: biogenesis, function, and a role as possible cancer biomarkers. Int J Genomics. 2017;2017:6218353. doi: 10.1155/2017/6218353. - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Biogenesis, cellular effects, and biomarker value of circHIPK3

Affiliations

Biogenesis, cellular effects, and biomarker value of circHIPK3

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

LinkOut - more resources

Full Text Sources

Other Literature Sources