Skip to main page content
U.S. flag

An official website of the United States government

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov;66(11):1069-1078.
doi: 10.1038/s10038-021-00933-x. Epub 2021 May 6.

The association between RAPSN methylation in peripheral blood and breast cancer in the Chinese population

Shuifang Lei #  1 , Lixi Li #  2 , Xiaoqin Yang  3 , Qiming Yin  1 , Tian Xu  4 , Wenjie Zhou  5 , Wanjian Gu  4 , Fei Ma  6 , Rongxi Yang  7
Affiliations

The association between RAPSN methylation in peripheral blood and breast cancer in the Chinese population

Shuifang Lei et al. J Hum Genet. 2021 Nov.

Abstract

DNA methylation in peripheral blood is associated with breast cancer (BC) but has mainly been studied in Caucasian populations. We investigated the association between blood-based methylation of receptor-associated protein of the synapse (RAPSN) and BC in Chinese population. The methylation levels of 12 RAPSN CpG sites were quantitatively evaluated by mass spectrometry in two case-control studies with 283 sporadic BC cases and 331 controls totally. The association was analyzed by logistic regression adjusted for covariants. The RAPSN methylation levels in patients with variant clinical characteristics were investigated by non-parametric tests. We found a significant association between BC and altered RAPSN methylation in blood in women at premenopausal and perimenopausal (age < 50 years old), but not in the elder women. This was approved by two independent case-control studies as well as by combining the subjects of the two studies (taken all subjects together, age < 50 years old, per 5% of methylation, odds ratio (OR) range from 1.17 to 1.30 for two CpG sites; OR = 0.75 for one CpG site; all p values < 0.02). This age-related RAPSN methylation was further modified by human epidermal growth factor receptor 2 (HER2) status (age < 50 years old, HER2 negative, per 5% of methylation, OR range from 1.27 to 1.48 for two CpG sites; OR = 0.76 for one CpG site; all p values < 0.02). We elucidated an association between BC and blood-based RAPSN methylation influenced by age and the status of HER2 in Chinese population.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–24. - PubMed - PMC
    1. Momenimovahed Z, Salehiniya H. Epidemiological characteristics of 577and risk factors for breast cancer in the world. Breast Cancer. 2019;11:151–64. - PubMed - PMC
    1. Rivera-Franco MM, Leon-Rodriguez E. Delays in breast cancer detection and treatment in developing countries. Breast Cancer. 2018;12:1178223417752677. - PubMed - PMC
    1. Jafari SH, Saadatpour Z, Salmaninejad A, Momeni F, Mokhtari M, Nahand JS, et al. Breast cancer diagnosis: imaging techniques and biochemical markers. J Cell Physiol. 2018;233:5200–13. - PubMed - DOI
    1. Baylin SB, Jones PA. Epigenetic Determinants of Cancer. Cold Spring Harb Perspect Biol. 2016;8. https://doi.org/10.1101/cshperspect.a019505 .

LinkOut - more resources