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Review
. 2021 Jul;32(7):488-499.
doi: 10.1016/j.tem.2021.04.005. Epub 2021 May 4.

Metabolic homeostasis via BDNF and its receptors

Brandon Podyma  1 , Kavya Parekh  2 , Ali D Güler  2 , Christopher D Deppmann  2
Affiliations
Review

Metabolic homeostasis via BDNF and its receptors

Brandon Podyma et al. Trends Endocrinol Metab. 2021 Jul.

Abstract

Metabolic disorders result from dysregulation of central nervous system and peripheral metabolic energy homeostatic pathways. To maintain normal energy balance, neural circuits must integrate feedforward and feedback signals from the internal metabolic environment to orchestrate proper food intake and energy expenditure. These signals include conserved meal and adipocyte cues such as glucose and leptin, respectively, in addition to more novel players including brain-derived neurotrophic factor (BDNF). In particular, BDNF's two receptors, tropomyosin related kinase B (TrkB) and p75 neurotrophin receptor (p75NTR), are increasingly appreciated to be involved in whole body energy homeostasis. At times, these two receptors even seem to functionally oppose one another's actions, providing the framework for a potential neurotrophin mediated energy regulatory axis, which we explore further here.

Keywords: BDNF; TrkB; hypothalamus; metabolism; neurotrophins; p75NTR.

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Conflict of interest statement

Declaration of interests No interests are declared.

Figures

Figure 1:
Figure 1:. Schematic representation of key hypothalamic regions and the expression of BDNF, p75NTR, and TrkB.
Arrows represent general connectivity between regions, and do not specify neurotrophin specific connections. Whether p75NTR and TrkB exist as independent or overlapping cell populations is unknown.
See this image and copyright information in PMC

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References

    1. Morton GJ et al. (2006) Central nervous system control of food intake and body weight. Nature 443, 289–295 - PubMed
    1. Andermann ML and Lowell BB (2017) Toward a wiring diagram understanding of appetite control. Neuron 95, 757–778 - PMC - PubMed
    1. Woods SC et al. (1998) Signals that regulate food intake and energy homeostasis. Science 280, 1378–1383 - PubMed
    1. Lewin GR and Barde YA (1996) Physiology of the neurotrophins. Annu. Rev. Neurosci. 19, 289–317 - PubMed
    1. Bibel M and Barde YA (2000) Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 14, 2919–2937 - PubMed

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