Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 May 25;118(21):e2106308118.
doi: 10.1073/pnas.2106308118.

PIP2 as the "coin of the realm" for neurovascular coupling

Scott Earley  1   2 , David Kleinfeld  3   4
Affiliations
Comment

PIP2 as the "coin of the realm" for neurovascular coupling

Scott Earley et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
The initial signaling events in functional hyperemia. (A and B) Neuronal action potentials induce hyperpolarizing pulses in capillary endothelial cells via buildup of extracellular [K+] to open Kir2.1 channels. Opening of these channels further requires binding of PIP2. (C) Hyperpolarizing pulses in capillary endothelial cells (ECs), caused by K+ flux through the opened Kir2.1 channels, are electrically conducted to upstream penetrating arterioles and induce dilation of the penetrating arterioles by relaxation of the associated smooth muscle. This leads to an elevated pressure head on the capillary network and an increase in red blood cell (RBC) flux. (Inset) Loss of PIP2 in the CADASIL small vessel disease (SVD) model prevents the opening of Kir2.1 channels and blocks functional hyperemia, while normal or restored levels of PIP2 support opening of Kir2.1 and a normal hemodynamic response.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

References

    1. Pantoni L., Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 9, 689–701 (2010). - PubMed
    1. Bosetti F.et al. .; “Small Blood Vessels: Big Health Problems” Workshop Participants , “Small blood vessels: Big health problems?”: Scientific recommendations of the National Institutes of Health Workshop. J. Am. Heart Assoc. 5, e004389 (2016). - PMC - PubMed
    1. Woolsey T. A., et al. ., Neuronal units linked to microvascular modules in cerebral cortex: Response elements for imaging the brain. Cereb. Cortex 6, 647–660 (1996). - PubMed
    1. Attwell D., Laughlin S. B., An energy budget for signaling in the grey matter of the brain. J. Cereb. Blood Flow Metab. 21, 1133–1145 (2001). - PubMed
    1. Girouard H., Iadecola C., Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. J Appl Physiol (1985) 100, 328–335 (2006). - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources