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. 2021 Apr;11(4):e361.
doi: 10.1002/ctm2.361.

Lipoprotein proteome profile: novel insight into hyperlipidemia

Miao Lin  1 , Menglin Li  1 , Hao Zheng  1 , Haidan Sun  2 , Jinlan Zhang  1
Affiliations

Lipoprotein proteome profile: novel insight into hyperlipidemia

Miao Lin et al. Clin Transl Med. 2021 Apr.
No abstract available

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

FIGURE 1
FIGURE 1
Protein overlaps in VLDL/LDL/HDL of golden hamsters and their specific functions. (A) Venn diagram of identified proteins in VLDL (V), LDL (L), and HDL (H) particles of golden hamsters. (B) Numbers of published (black) or newly detected (red) proteins compared with the VLDL/LDL/HDL proteome lists (Excel S1‐1/2/3). (C) Numbers of validated proteins by PRM proteomics. Black: total numbers; red: numbers of new proteins. (D‐J) Abundance heatmaps of 46 validated proteins in VLDL/LDL/HDL of normal golden hamsters using PRM targeted data. Left: Heatmaps of protein abundance. Right: Ten functional panels organized by biological functions and protein‐protein interaction in the STRING database. Each protein abundance in lipoprotein particles was from the normalized abundance by PRM quantitative proteomics. A value of 1.00 was assigned to the highest abundance of the specific protein among three lipoproteins, and other ratios were calculated accordingly. The highest value to the lowest are colored from red to green.
FIGURE 2
FIGURE 2
The regulatory networks of VLDL, LDL, and HDL differential proteins in hyperlipidemic golden hamsters by IPA software with label‐free proteomic data. (A) Top 3 networks associated with diseases and bio‐functions. (B) VLDL top network. (C) LDL top network. (D) VLDL top network. Red color: upregulated proteins; green color: downregulated proteins; orange star: validated differential proteins
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