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. 2021 Mar 28;46(3):300-308.
doi: 10.11817/j.issn.1672-7347.2021.190744.

Epstein - Barr virus - encoded microRNAs involve in tumorigenesis and development

[Article in English, Chinese]
Weiming Li  1   2 , Weihong Yi  3 , Dazhi Yang  3 , Guiyuan Li  4
Affiliations

Epstein - Barr virus - encoded microRNAs involve in tumorigenesis and development

[Article in English, Chinese]
Weiming Li et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. .

Abstract
in English, Chinese

Epstein-Barr virus (EBV), a definite tumorigenic virus, is closely related to the development of nasopharyngeal cancer, gastric cancer, lymphoma and other tumors. EBV encodes a total of 44 mature microRNAs, which can regulate the expression of virus and host genes. EBV-encoded microRNAs and their regulated target molecules participate in the biological functions of tumor apoptosis, proliferation, invasion, and metastasis during tumorigenesis and development, and play an important role in the development of tumor.

EB病毒(Epstein-Barr virus，EBV)是一种明确的致瘤性病毒，与鼻咽癌、胃癌、淋巴瘤等多种肿瘤的发生和发展密切相关。EBV共编码44种成熟的微RNA(microRNAs，miRNAs)，可调节病毒自身和宿主基因的表达。EBV编码的miRNAs(Epstein-Barr virus-encoded microRNAs，EBV miRNAs)及其所调控的靶分子参与肿瘤细胞的凋亡、增殖、侵袭和转移等方面的生物学功能，在肿瘤发生和发展过程中发挥重要作用。.

Keywords: Epstein-Barr virus-encoded microRNAs; epithelial-mesenchymal transition; latent infection; tumor.

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Conflict of interest statement

作者声称无任何利益冲突。

Figures

图1
图1
25种EBV miRNAs前体与潜伏基因在基因组上的相对位置 Figure 1 Relative position of 25 EBV miRNA precursors and EBV latent genes on the genome
See this image and copyright information in PMC

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