Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr 10;11(4):333.
doi: 10.3390/life11040333.

Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis

Wanda Niepiekło-Miniewska  1 , Łukasz Matusiak  2 , Joanna Narbutt  3 , Alekandra Lesiak  3 , Piotr Kuna  4   5 , Andrzej Wiśniewski  1 , Piotr Kuśnierczyk  1
Affiliations

Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis

Wanda Niepiekło-Miniewska et al. Life (Basel). .

Abstract

Atopic dermatitis (AD) is a chronic and recurrent inflammatory dermatosis. We recently described an association of the C allele of the single nucleotide polymorphism (SNP) rs26618 in the ERAP1 gene and a synergism of ERAP1 and ERAP2 effects on AD risk. Here, we examined whether polymorphisms of other antigen-presenting machinery genes encoding immunoproteasome components LMP2 and LMP7 and peptide transporter components TAP1 and TAP2 may also affect susceptibility to AD or its outcome. We found that the LMP7 rs2071543*T allele decreased disease risk by about 1.5-fold (odds ratio 0.66, 95% confidence interval 0.44-0.99). On the other hand, the LMP2 rs1351383*C allele reduced the mean age at diagnosis from 23 to 15 years (p < 0.001). Similarly, the TAP1 rs1135216*C allele decreased the mean age at diagnosis from almost 20 to 14 years (p = 0.033). The results are discussed in light of other reports on the role of these polymorphisms in human disease.

Keywords: LMP2; LMP7; TAP1; TAP2; atopic dermatitis; genetics.

PubMed Disclaimer

Conflict of interest statement

All authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Scheme of LMP and TAP gene region.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Bieber T. Atopic dermatitis. Ann. Dermatol. 2010;22:125–137. doi: 10.5021/ad.2010.22.2.125. - DOI - PMC - PubMed
    1. Nutten S. Atopic dermatitis: Global epidemiology and risk factors. Ann. Nutr. Metab. 2015;66(Suppl. S1):8–16. doi: 10.1159/000370220. - DOI - PubMed
    1. Kapur S., Watson W., Carr S. Atopic dermatitis. Allergy Asthma Clin. Immunol. 2018:12–52. doi: 10.1186/s13223-018-0281-6. - DOI - PMC - PubMed
    1. Turner J.D., Schwartz R.A. Atopic dermatitis. A clinical challenge. Acta Dermatovenerol. Alpina Pannonica Adriatica. 2006;15:59–68. - PubMed
    1. Thomsen S.F. Epidemiology and natural history of atopic diseases. Eur. Clin. Respir. J. 2015;24:2. doi: 10.3402/ecrj.v2.24642. - DOI - PMC - PubMed

LinkOut - more resources