Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr 1;11(4):305.
doi: 10.3390/life11040305.

Association between Vascular Inflammation and Inflammation in Adipose Tissue, Spleen, and Bone Marrow in Patients with Psoriasis

Hannah Kaiser  1   2   3 , Amanda Kvist-Hansen  1   2   3 , Martin Krakauer  4   5 , Peter Michael Gørtz  4 , Kristoffer Mads Aaris Henningsen  1 , Xing Wang  6 , Christine Becker  6   7 , Claus Zachariae  2   3 , Lone Skov  2   3 , Peter Riis Hansen  1   3
Affiliations

Association between Vascular Inflammation and Inflammation in Adipose Tissue, Spleen, and Bone Marrow in Patients with Psoriasis

Hannah Kaiser et al. Life (Basel). .

Abstract

Psoriasis is associated with atherosclerotic cardiovascular disease (CVD) with significant overlap of inflammatory pathways. A link between vascular inflammation and inflammation in multiple adipose tissue types, spleen, and bone marrow may exist. Therefore, we investigated these associations using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in patients with psoriasis (n = 83) where half had established CVD. Carotid ultrasound imaging was also performed. Inflammation was measured by FDG uptake in the aorta, visceral- (VAT), subcutaneous- (SAT), and pericardial (PAT) adipose tissues, and spleen and bone marrow, respectively. Vascular inflammation was associated with FDG uptakes in all adipose tissues, including VAT (β = 0.26; p < 0.001), SAT (β = 0.28; p < 0.001), PAT (β = 0.24; p < 0.001), spleen (β = 1.35; p = 0.001), and bone marrow (β = 1.14; p < 0.001). Adjustments for age, sex, body mass index, and high sensitivity C-reactive protein did not change the results. These associations were generally preserved in the patients without prior CVD. No associations were observed between vascular inflammation and carotid intima-media thickness or presence of carotid plaques, respectively. The results suggest an inflammatory link between vascular and adipose tissues, spleen, and bone marrow in patients with psoriasis.

Keywords: 18F-FDG-PET/CT; adipose tissue; cardiovascular disease; psoriasis; vascular inflammation.

PubMed Disclaimer

Conflict of interest statement

P.R.H. is recipient of a Borregaard clinical scientist fellowship from the NOVO Nordisk Foundation and chairs a clinical academic group supported by the Greater Region of Copenhagen. C.B. is a consultant for Onegevity Health. L.S. has been a paid speaker for AbbVie, Eli Lilly, and LEO Pharma and has been a consultant or served on Advisory Boards with AbbVie, Janssen Cilag, Novartis, Eli Lilly, LEO Pharma, UCB, Admirall, and Sanofi. She has served as an investigator for AbbVie, Janssen Cilag, Boehringer Ingelheim, AstraZenica, Eli Lilly, Novartis, Regeneron, and LEO Pharma and received research and educational grant from Pfizer, AbbVie, Novartis, Sanofi, Janssen Cilag, and Leo Pharma. C.Z. has been scientific consultant, advisor, investigator and speaker for Eli Lilly, Jansen Cilag, Novartis, Abb Vie, Takeda, Amgen, Almirall, CSL, UCB, Regeneron, MSD, and Leo Pharma. H.K., A.K.H., M.K., P.M.G., K.M.A.H., XW declare that they have no competing interests.

Figures

Figure 1
Figure 1
Transverse and coronal images from computed tomography (left) with corresponding positron emission tomography (right) with arrows indicating regions-of-interests (ROIs) drawn in (a) visceral and subcutaneous adipose tissue, (b) pericardial adipose tissue, (c) ascending and descending aorta and superior vena cava, (d) spleen and liver, and (e) bone marrow (lumbar vertebrae 1–5). SUV, standardized uptake value.
Figure 2
Figure 2
Regression plots of associations between 18F-fluorodeoxyglucose (FDG) uptake in the entire aorta and FDG uptake in (a) visceral-, (b) subcutaneous-, and (c) pericardial adipose tissue, (d) spleen-to-liver ratio, and (e) bone marrow-to-liver ratio in all patients with psoriasis (n = 83) examined by 18F-fluorodeoxyglucose positron emission tomography/computed tomography. Regression coefficients; β = unadjusted, β* = adjusted for age, sex, body mass index, and high-sensitivity C-reactive protein. Shaded regions represent 95% confidence intervals for the fitted regression models. Visceral-, subcutaneous-, and pericardial adipose tissue values were log2transformed. TBR: target-to-background ratio.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Takeshita J., Grewal S., Langan S.M., Mehta N.N., Ogdie A., Van Voorhees A.S., Gelfand J.M. Psoriasis and comorbid diseases: Epidemiology. J. Am. Acad. Dermatol. 2017;76:377–390. doi: 10.1016/j.jaad.2016.07.064. - DOI - PMC - PubMed
    1. Reich K. The concept of psoriasis as a systemic inflammation: Implications for disease management. J. Eur. Acad. Dermatol. Venereol. 2012;26:3–11. doi: 10.1111/j.1468-3083.2011.04410.x. - DOI - PubMed
    1. Armstrong E.J., Harskamp C.T., Armstrong A.W. Psoriasis and major adverse cardiovascular events: A systematic review and meta-analysis of observational studies. J. Am. Heart Assoc. 2013;2:e000062. doi: 10.1161/JAHA.113.000062. - DOI - PMC - PubMed
    1. Mehta N.N., Yu Y.D., Saboury B., Foroughi N., Krishnamoorthy P., Raper A., Baer A., Antigua J., Van Voorhees A.S., Torigian D.A., et al. Systemic and vascular inflammation in patients with moderate to severe psoriasis as measured by [18F]-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT): A pilot study. Arch. Dermatol. 2011;147:1031–1039. doi: 10.1001/archdermatol.2011.119. - DOI - PMC - PubMed
    1. Hjuler K.F., Gormsen L.C., Vendelbo M.H., Egeberg A., Nielsen J., Iversen L. Increased global arterial and subcutaneous adipose tissue inflammation in patients with moderate-to-severe psoriasis. Br. J. Dermatol. 2017;176:732–740. doi: 10.1111/bjd.15149. - DOI - PubMed

Grants and funding

LinkOut - more resources