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Review
. 2022;62(26):7282-7300.
doi: 10.1080/10408398.2021.1913400. Epub 2021 Apr 27.

Superoxide dismutase: an updated review on its health benefits and industrial applications

Mohammad Nazmul Islam  1 , Abdur Rauf  2 , Fowzul Islam Fahad  1 , Talha Bin Emran  3 , Saikat Mitra  4 , Ahmed Olatunde  5 , Mohammad Ali Shariati  6 , Maksim Rebezov  7   8 , Kannan R R Rengasamy  9 , Mohammad S Mubarak  10
Affiliations
Review

Superoxide dismutase: an updated review on its health benefits and industrial applications

Mohammad Nazmul Islam et al. Crit Rev Food Sci Nutr. 2022.

Abstract

Many short-lived and highly reactive oxygen species, such as superoxide anion (O2-) and hydrogen peroxide (H2O2), are toxic or can create oxidative stress in cells, a response involved in the pathogenesis of numerous diseases depending on their concentration, location, and cellular conditions. Superoxide dismutase (SOD) activities as an endogenous and exogenous cell defense mechanism include the potential use in treating various diseases, improving the potential use in treating various diseases, and improving food-stuffs preparation dietary supplements human nutrition. Published work indicates that SOD regulates oxidative stress, lipid metabolism, inflammation, and oxidation in cells. It can prevent lipid peroxidation, the oxidation of low-density lipoprotein in macrophages, lipid droplets' formation, and the adhesion of inflammatory cells into endothelial monolayers. It also expresses antioxidant effects in numerous cancer-related processes. Additionally, different forms of SOD may also augment food processing and pharmaceutical applications, exhibit anticancer, antioxidant, and anti-inflammatory effects, and prevent arterial problems by protecting the proliferation of vascular smooth muscle cells. Many investigations in this review have reported the therapeutic ability and physiological importance of SOD. Because of their antioxidative effects, SODs are of great potential in the medicinal, cosmetic, food, farming and chemical industries. This review discusses the findings of human and animal studies that support the advantages of SOD enzyme regulations to reduce the formation of oxidative stress in various ways.

Keywords: Antioxidant; cancer; dietary supplement; food science; human nutrition; superoxide dismutase.

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