Non-human primate models of human respiratory infections

doi:10.1016/j.molimm.2021.04.010

Review

. 2021 Jul:135:147-164.

doi: 10.1016/j.molimm.2021.04.010. Epub 2021 Apr 23.

Non-human primate models of human respiratory infections

Julien Lemaitre¹, Thibaut Naninck¹, Benoît Delache¹, Justina Creppy², Philippe Huber¹, Marion Holzapfel¹, Camille Bouillier¹, Vanessa Contreras¹, Frédéric Martinon¹, Nidhal Kahlaoui¹, Quentin Pascal¹, Sabine Tricot¹, Frédéric Ducancel¹, Laurent Vecellio³, Roger Le Grand¹, Pauline Maisonnasse⁴

Affiliations

¹ Université Paris-Saclay, INSERM, CEA, Center for Immunology of Viral, Autoimmune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
² Université Paris-Saclay, INSERM, CEA, Center for Immunology of Viral, Autoimmune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France; Centre d'Etude des Pathologies Respiratoires, INSERM U1100, Université de Tours, Tours, France.
³ Centre d'Etude des Pathologies Respiratoires, INSERM U1100, Université de Tours, Tours, France; Plateforme Scientifique et Technique Animaleries (PST-A), Université de Tours, Tours, France.
⁴ Université Paris-Saclay, INSERM, CEA, Center for Immunology of Viral, Autoimmune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France. Electronic address: pauline.maisonnasse@cea.fr.

PMID: 33895579
PMCID: PMC8062575
DOI: 10.1016/j.molimm.2021.04.010

Review

Non-human primate models of human respiratory infections

Julien Lemaitre et al. Mol Immunol. 2021 Jul.

. 2021 Jul:135:147-164.

doi: 10.1016/j.molimm.2021.04.010. Epub 2021 Apr 23.

Authors

Affiliations

¹ Université Paris-Saclay, INSERM, CEA, Center for Immunology of Viral, Autoimmune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
² Université Paris-Saclay, INSERM, CEA, Center for Immunology of Viral, Autoimmune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France; Centre d'Etude des Pathologies Respiratoires, INSERM U1100, Université de Tours, Tours, France.
³ Centre d'Etude des Pathologies Respiratoires, INSERM U1100, Université de Tours, Tours, France; Plateforme Scientifique et Technique Animaleries (PST-A), Université de Tours, Tours, France.
⁴ Université Paris-Saclay, INSERM, CEA, Center for Immunology of Viral, Autoimmune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France. Electronic address: pauline.maisonnasse@cea.fr.

PMID: 33895579
PMCID: PMC8062575
DOI: 10.1016/j.molimm.2021.04.010

Abstract

Respiratory pathogens represent a great burden for humanity and a potential source of new pandemics, as illustrated by the recent emergence of coronavirus disease 2019 (COVID-19). In recent decades, biotechnological advances have led to the development of numerous innovative therapeutic molecules and vaccine immunogens. However, we still lack effective treatments and vaccines against many respiratory pathogens. More than ever, there is a need for a fast, predictive, preclinical pipeline, to keep pace with emerging diseases. Animal models are key for the preclinical development of disease management strategies. The predictive value of these models depends on their ability to reproduce the features of the human disease, the mode of transmission of the infectious agent and the availability of technologies for monitoring infection. This review focuses on the use of non-human primates as relevant preclinical models for the development of prevention and treatment for human respiratory infections.

Keywords: Bacteria; Infectious disease; Non-human primate; Respiratory tract; Virus.

PubMed Disclaimer

Conflict of interest statement

The authors report no declarations of interest.

Figures

**Fig. 1**
PET-CT images of [¹⁸F]-FDG uptake in a cynomolgus macaque. **(A)** Chest frontal slice with lymph node hypermetabolism in the clavicular (brown arrow), mediastinal (red arrow) and axillary (yellow arrow) regions. (**B-C**) Transverse slice with hypermetabolism in the tonsil (blue arrow), nasopharynx-associated lymphoid tissue (purple arrow) and lymph node in cervical regions (green arrow). (D) 3D representation of [¹⁸F]-FDG hypermetabolism.

See this image and copyright information in PMC

Cited by

Special Issue "Immune Ontogeny and Vaccination in Early Life: How the Non-Human Primate Model Can Help Expand the Current Knowledge in Pediatric Immunology and Infectious Diseases Research".
Seddiki N, Le Grand R. Seddiki N, et al. Vaccines (Basel). 2021 Sep 12;9(9):1014. doi: 10.3390/vaccines9091014. Vaccines (Basel). 2021. PMID: 34579251 Free PMC article.
Defining a core breath profile for healthy, non-human primates.
Bobak CA, Stevenson KAJM, Sun N, Khan MS, Azmir J, Beccaria M, Tomko JA, Fillmore D, Scanga CA, Lin PL, Flynn JL, Hill JE. Bobak CA, et al. Sci Rep. 2024 Jul 23;14(1):17031. doi: 10.1038/s41598-024-64910-y. Sci Rep. 2024. PMID: 39043722 Free PMC article.
Computed tomography and [¹⁸F]-FDG PET imaging provide additional readouts for COVID-19 pathogenesis and therapies evaluation in non-human primates.
Naninck T, Kahlaoui N, Lemaitre J, Maisonnasse P, De Mori A, Pascal Q, Contreras V, Marlin R, Relouzat F, Delache B, Hérate C, Aldon Y, van Gils M, Zabaleta N, Ho Tsong Fang R, Bosquet N, Sanders RW, Vandenberghe LH, Chapon C, Le Grand R. Naninck T, et al. iScience. 2022 Apr 15;25(4):104101. doi: 10.1016/j.isci.2022.104101. Epub 2022 Mar 17. iScience. 2022. PMID: 35313622 Free PMC article.
The Isolation and In Vitro Differentiation of Primary Fetal Baboon Tracheal Epithelial Cells for the Study of SARS-CoV-2 Host-Virus Interactions.
Subramaniyan B, Gurung S, Bodas M, Moore AR, Larabee JL, Reuter D, Georgescu C, Wren JD, Myers DA, Papin JF, Walters MS. Subramaniyan B, et al. Viruses. 2023 Mar 28;15(4):862. doi: 10.3390/v15040862. Viruses. 2023. PMID: 37112842 Free PMC article.
Fungal Rhinosinusitis Caused by a Curvularia sp. Infection in a Female Sumatran Orangutan: A Case Report.
Uwiera RRE, Vijayasekaran S, Wallace AM, Reese DJ, Walsh AL, Uwiera TC, Vaughan-Higgins R, Vitali SD. Uwiera RRE, et al. Pathogens. 2022 Oct 9;11(10):1166. doi: 10.3390/pathogens11101166. Pathogens. 2022. PMID: 36297223 Free PMC article.

See all "Cited by" articles

References

1. Albuquerque-Silva I., Vecellio L., Durand M., Avet J., Le Pennec D., de Monte M., Montharu J., Diot P., Cottier M., Dubois F., Pourchez J. Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons. PLoS One. 2014;9 - PMC - PubMed
1. Alsved M., Bourouiba L., Duchaine C., Löndahl J., Marr L.C., Parker S.T., Prussin A.J., Thomas R.J. Natural sources and experimental generation of bioaerosols: challenges and perspectives. Aerosol Sci. Technol. 2020;54:547–571.
1. Altamirano-Lagos M.J., Diaz F.E., Mansilla M.A., Rivera-Perez D., Soto D., McGill J.L., Vasquez A.E., Kalergis A.M. Current animal models for understanding the pathology caused by the respiratory syncytial virus. Front. Microbiol. 2019;10:873. - PMC - PubMed
1. Andabaka T., Nickerson J.W., Rojas-Reyes M.X., Rueda J.D., Bacic Vrca V., Barsic B. Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children. Cochrane Database Syst. Rev. 2013 - PubMed
1. Arabi Y.M., Balkhy H.H., Hayden F.G., Bouchama A., Luke T., Baillie J.K., Al-Omari A., Hajeer A.H., Senga M., Denison M.R., Nguyen-Van-Tam J.S., Shindo N., Bermingham A., Chappell J.D., Van Kerkhove M.D., Fowler R.A. Middle east respiratory syndrome. N. Engl. J. Med. 2017;376:584–594. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Albuquerque-Silva I., Vecellio L., Durand M., Avet J., Le Pennec D., de Monte M., Montharu J., Diot P., Cottier M., Dubois F., Pourchez J. Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons. PLoS One. 2014;9 - PMC - PubMed

[2] Albuquerque-Silva I., Vecellio L., Durand M., Avet J., Le Pennec D., de Monte M., Montharu J., Diot P., Cottier M., Dubois F., Pourchez J. Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons. PLoS One. 2014;9 - PMC - PubMed

[3] Alsved M., Bourouiba L., Duchaine C., Löndahl J., Marr L.C., Parker S.T., Prussin A.J., Thomas R.J. Natural sources and experimental generation of bioaerosols: challenges and perspectives. Aerosol Sci. Technol. 2020;54:547–571.

[4] Alsved M., Bourouiba L., Duchaine C., Löndahl J., Marr L.C., Parker S.T., Prussin A.J., Thomas R.J. Natural sources and experimental generation of bioaerosols: challenges and perspectives. Aerosol Sci. Technol. 2020;54:547–571.

[5] Altamirano-Lagos M.J., Diaz F.E., Mansilla M.A., Rivera-Perez D., Soto D., McGill J.L., Vasquez A.E., Kalergis A.M. Current animal models for understanding the pathology caused by the respiratory syncytial virus. Front. Microbiol. 2019;10:873. - PMC - PubMed

[6] Altamirano-Lagos M.J., Diaz F.E., Mansilla M.A., Rivera-Perez D., Soto D., McGill J.L., Vasquez A.E., Kalergis A.M. Current animal models for understanding the pathology caused by the respiratory syncytial virus. Front. Microbiol. 2019;10:873. - PMC - PubMed

[7] Andabaka T., Nickerson J.W., Rojas-Reyes M.X., Rueda J.D., Bacic Vrca V., Barsic B. Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children. Cochrane Database Syst. Rev. 2013 - PubMed

[8] Andabaka T., Nickerson J.W., Rojas-Reyes M.X., Rueda J.D., Bacic Vrca V., Barsic B. Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children. Cochrane Database Syst. Rev. 2013 - PubMed

[9] Arabi Y.M., Balkhy H.H., Hayden F.G., Bouchama A., Luke T., Baillie J.K., Al-Omari A., Hajeer A.H., Senga M., Denison M.R., Nguyen-Van-Tam J.S., Shindo N., Bermingham A., Chappell J.D., Van Kerkhove M.D., Fowler R.A. Middle east respiratory syndrome. N. Engl. J. Med. 2017;376:584–594. - PMC - PubMed

[10] Arabi Y.M., Balkhy H.H., Hayden F.G., Bouchama A., Luke T., Baillie J.K., Al-Omari A., Hajeer A.H., Senga M., Denison M.R., Nguyen-Van-Tam J.S., Shindo N., Bermingham A., Chappell J.D., Van Kerkhove M.D., Fowler R.A. Middle east respiratory syndrome. N. Engl. J. Med. 2017;376:584–594. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Non-human primate models of human respiratory infections

Affiliations

Non-human primate models of human respiratory infections

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical