Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes

doi:10.1016/S1473-3099(21)00201-2

Comment

. 2021 Sep;21(9):1195-1197.

doi: 10.1016/S1473-3099(21)00201-2. Epub 2021 Apr 12.

Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes

Sean Wei Xiang Ong¹, Barnaby Edward Young², David Chien Lye³

Affiliations

¹ National Centre for Infectious Diseases, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore.
² National Centre for Infectious Diseases, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
³ National Centre for Infectious Diseases, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: david_lye@ncid.sg.

PMID: 33857407
PMCID: PMC8041357
DOI: 10.1016/S1473-3099(21)00201-2

Comment

Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes

Sean Wei Xiang Ong et al. Lancet Infect Dis. 2021 Sep.

. 2021 Sep;21(9):1195-1197.

doi: 10.1016/S1473-3099(21)00201-2. Epub 2021 Apr 12.

Authors

Sean Wei Xiang Ong¹, Barnaby Edward Young², David Chien Lye³

Affiliations

¹ National Centre for Infectious Diseases, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore.
² National Centre for Infectious Diseases, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
³ National Centre for Infectious Diseases, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: david_lye@ncid.sg.

PMID: 33857407
PMCID: PMC8041357
DOI: 10.1016/S1473-3099(21)00201-2

No abstract available

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Conflict of interest statement

BEY reports personal fees from Roche and Sanofi, outside the submitted work. All other authors declare no competing interests.

Comment on

Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study.
Frampton D, Rampling T, Cross A, Bailey H, Heaney J, Byott M, Scott R, Sconza R, Price J, Margaritis M, Bergstrom M, Spyer MJ, Miralhes PB, Grant P, Kirk S, Valerio C, Mangera Z, Prabhahar T, Moreno-Cuesta J, Arulkumaran N, Singer M, Shin GY, Sanchez E, Paraskevopoulou SM, Pillay D, McKendry RA, Mirfenderesky M, Houlihan CF, Nastouli E. Frampton D, et al. Lancet Infect Dis. 2021 Sep;21(9):1246-1256. doi: 10.1016/S1473-3099(21)00170-5. Epub 2021 Apr 12. Lancet Infect Dis. 2021. PMID: 33857406 Free PMC article.

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References

1. Davies NG, Abbott S, Barnard RC, et al. Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science. 2021 doi: 10.1126/science.abg3055. published online March 3. - DOI - PMC - PubMed
1. Leung K, Shum MH, Leung GM, Lam TT, Wu JT. Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020. Euro Surveill. 2021;26 - PMC - PubMed
1. Frampton D, Rampling T, Cross A, et al. Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study. Lancet Infect Dis. 2021 doi: 10.1016/S1473-3099(21)00170-5. published online April 12. - DOI - PMC - PubMed
1. Kidd M, Richter A, Best A, et al. S-variant SARS-CoV-2 lineage B1.1.7 is associated with significantly higher viral loads in samples tested by ThermoFisher TaqPath RT-qPCR. J Infect Dis. 2021 - PMC - PubMed
1. Calistri P, Amato L, Puglia I, et al. Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs. Int J Infect Dis. 2021 doi: 10.1016/j.ijid.2021.03.005. published online March 5. - DOI - PMC - PubMed

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[1] Davies NG, Abbott S, Barnard RC, et al. Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science. 2021 doi: 10.1126/science.abg3055. published online March 3. - DOI - PMC - PubMed

[2] Davies NG, Abbott S, Barnard RC, et al. Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science. 2021 doi: 10.1126/science.abg3055. published online March 3. - DOI - PMC - PubMed

[3] Leung K, Shum MH, Leung GM, Lam TT, Wu JT. Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020. Euro Surveill. 2021;26 - PMC - PubMed

[4] Leung K, Shum MH, Leung GM, Lam TT, Wu JT. Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020. Euro Surveill. 2021;26 - PMC - PubMed

[5] Frampton D, Rampling T, Cross A, et al. Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study. Lancet Infect Dis. 2021 doi: 10.1016/S1473-3099(21)00170-5. published online April 12. - DOI - PMC - PubMed

[6] Frampton D, Rampling T, Cross A, et al. Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study. Lancet Infect Dis. 2021 doi: 10.1016/S1473-3099(21)00170-5. published online April 12. - DOI - PMC - PubMed

[7] Kidd M, Richter A, Best A, et al. S-variant SARS-CoV-2 lineage B1.1.7 is associated with significantly higher viral loads in samples tested by ThermoFisher TaqPath RT-qPCR. J Infect Dis. 2021 - PMC - PubMed

[8] Kidd M, Richter A, Best A, et al. S-variant SARS-CoV-2 lineage B1.1.7 is associated with significantly higher viral loads in samples tested by ThermoFisher TaqPath RT-qPCR. J Infect Dis. 2021 - PMC - PubMed

[9] Calistri P, Amato L, Puglia I, et al. Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs. Int J Infect Dis. 2021 doi: 10.1016/j.ijid.2021.03.005. published online March 5. - DOI - PMC - PubMed

[10] Calistri P, Amato L, Puglia I, et al. Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs. Int J Infect Dis. 2021 doi: 10.1016/j.ijid.2021.03.005. published online March 5. - DOI - PMC - PubMed

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Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes

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Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes

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