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Review
. 2021 Aug;15(8):1013-1023.
doi: 10.1080/17476348.2021.1913060. Epub 2021 Apr 13.

Ventilation management in acute respiratory failure related to COVID-19 versus ARDS from another origin - a descriptive narrative review

Anissa M Tsonas  1 , Michela Botta  1 , Ary Serpa Neto  1   2   3   4   5 , Janneke Horn  1   6 , Frederique Paulus  1   7 , Marcus J Schultz  1   8   9
Affiliations
Review

Ventilation management in acute respiratory failure related to COVID-19 versus ARDS from another origin - a descriptive narrative review

Anissa M Tsonas et al. Expert Rev Respir Med. 2021 Aug.

Abstract

Introduction: It is uncertain whether ventilation in patients with acute respiratory failure related to coronavirus disease 2019 (COVID-19) differs from that in patients with acute respiratory distress syndrome (ARDS) from another origin.

Areas covered: We undertook two literature searches in PubMed to identify observational studies reporting on ventilation management--one in patients with acute respiratory failure related to COVID-19, and one in patients with ARDS from another origin. The searches identified 14 studies in patients with acute respiratory failure related to COVID-19, and 8 studies in patients with ARDS from another origin.

Expert opinion: In patients with acute respiratory failure related to COVID-19, ventilation management seems to be similar to that of patients with ARDS from another origin. The future lies in studies focused on personalized treatment of ARDS of all origins, including COVID-19.

Keywords: Acute respiratory distress syndrome; COVID-19; acute respiratory failure; coronavirus disease 2019; invasive ventilation; oxygen fraction; peep; prone positioning; tidal volume; ventilation management.

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Figures

Figure 1.
Figure 1.
Search results
Figure 2.
Figure 2.
Summary of ventilation settings in patients with acute respiratory failure related to COVID-19 versus in patients with ARDS from another origin. references are provided between square brackets. green fonts: median or mean VT ≤ 8 ml/kg PBW, PEEP ≤ 10 cm H2O, FiO2 ≤ 60%, and prone ventilation use ≥ 15% – red fonts: median or mean VT > 8 ml/kg PBW, PEEP > 10 cm H2O, FiO2 > 60%, and prone ventilation use < 15% (cutoffs are arbitrarily chosen)
See this image and copyright information in PMC

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