The emerging regulatory roles of long non-coding RNAs implicated in cancer metabolism

doi:10.1016/j.ymthe.2021.03.017

Review

. 2021 Jul 7;29(7):2209-2218.

doi: 10.1016/j.ymthe.2021.03.017. Epub 2021 Mar 26.

The emerging regulatory roles of long non-coding RNAs implicated in cancer metabolism

Yongcan Xu¹, Mantang Qiu², Minmin Shen³, Shunli Dong⁴, Guochao Ye¹, Xuefei Shi⁵, Ming Sun⁶

Affiliations

¹ Department of General Surgery, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou 313000, People's Republic of China.
² Department of Thoracic Surgery, Peking University People's Hospital, Beijing, People's Republic of China.
³ Drug Clinical Trial Institution Office, Huzhou Central Hospital, Affiliated Central Hospital, Huzhou University, Huzhou, People's Republic of China.
⁴ Department of Central Laboratory, Huzhou Central Hospital, Affiliated Central Hospital, Huzhou University, Huzhou, People's Republic of China.
⁵ Department of Respiratory Medicine, Huzhou Central Hospital, Affiliated Central Hospital, Huzhou University, Huzhou 313000, People's Republic of China. Electronic address: shixuefei1223@aliyun.com.
⁶ Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, People's Republic of China; Suzhou Cancer Center, Gusu School of Nanjing Medical University Suzhou, Jiangsu, People's Republic of China. Electronic address: summing348@hotmail.com.

PMID: 33775912
PMCID: PMC8261164
DOI: 10.1016/j.ymthe.2021.03.017

Review

The emerging regulatory roles of long non-coding RNAs implicated in cancer metabolism

Yongcan Xu et al. Mol Ther. 2021.

. 2021 Jul 7;29(7):2209-2218.

doi: 10.1016/j.ymthe.2021.03.017. Epub 2021 Mar 26.

Authors

Yongcan Xu¹, Mantang Qiu², Minmin Shen³, Shunli Dong⁴, Guochao Ye¹, Xuefei Shi⁵, Ming Sun⁶

Affiliations

¹ Department of General Surgery, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou 313000, People's Republic of China.
² Department of Thoracic Surgery, Peking University People's Hospital, Beijing, People's Republic of China.
³ Drug Clinical Trial Institution Office, Huzhou Central Hospital, Affiliated Central Hospital, Huzhou University, Huzhou, People's Republic of China.
⁴ Department of Central Laboratory, Huzhou Central Hospital, Affiliated Central Hospital, Huzhou University, Huzhou, People's Republic of China.
⁵ Department of Respiratory Medicine, Huzhou Central Hospital, Affiliated Central Hospital, Huzhou University, Huzhou 313000, People's Republic of China. Electronic address: shixuefei1223@aliyun.com.
⁶ Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, People's Republic of China; Suzhou Cancer Center, Gusu School of Nanjing Medical University Suzhou, Jiangsu, People's Republic of China. Electronic address: summing348@hotmail.com.

PMID: 33775912
PMCID: PMC8261164
DOI: 10.1016/j.ymthe.2021.03.017

Abstract

Compared to normal cells, cancer cells exhibit specific metabolic characteristics that facilitate the growth and metastasis of cancer. It is now widely appreciated that long non-coding RNAs (lncRNAs) exert extensive regulatory effects on a spectrum of biological processes through diverse mechanisms. In this review, we focus on the rapidly advancing field of lncRNAs and summarize the relationship between the dysregulation of lncRNAs and cancer metabolism, with a particular emphasis on the specific roles of lncRNAs in glycolysis, mitochondrial function, glutamine, and lipid metabolism. These investigations reveal that lncRNAs are a key factor in the complexity of malignant cancer metabolism. Only through understanding the relevance between lncRNAs and cancer metabolic reprogramming can we open a new chapter in the history of carcinogenesis, one that promises to alter the methods of cancer diagnosis and treatment.

Keywords: cancer metabolism; lncRNA; regulatory mechanism; reprogramming.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

**Figure 1**
Classification of lncRNAs lncRNAs can be further subclassified into divergent, overlapping, intronic, and intergenic lncRNAs on the grounds of their intersection with protein-coding genes.

**Figure 2**
Schematic illustration of lncRNAs involved in the metabolic rearrangement of cancer metabolism by targeting metabolism-related molecules or pathways Detailed mechanisms of these lncRNAs are described in the main text.

See this image and copyright information in PMC

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References

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[1] Sun H., Huang Z., Sheng W., Xu M.D. Emerging roles of long non-coding RNAs in tumor metabolism. J. Hematol. Oncol. 2018;11:106. - PMC - PubMed

[2] Sun H., Huang Z., Sheng W., Xu M.D. Emerging roles of long non-coding RNAs in tumor metabolism. J. Hematol. Oncol. 2018;11:106. - PMC - PubMed

[3] Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell. 2011;144:646–674. - PubMed

[4] Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell. 2011;144:646–674. - PubMed

[5] Wang J., Zhang X., Chen W., Hu X., Li J., Liu C. Regulatory roles of long noncoding RNAs implicated in cancer hallmarks. Int. J. Cancer. 2020;146:906–916. - PubMed

[6] Wang J., Zhang X., Chen W., Hu X., Li J., Liu C. Regulatory roles of long noncoding RNAs implicated in cancer hallmarks. Int. J. Cancer. 2020;146:906–916. - PubMed

[7] Pavlova N.N., Thompson C.B. The Emerging Hallmarks of Cancer Metabolism. Cell Metab. 2016;23:27–47. - PMC - PubMed

[8] Pavlova N.N., Thompson C.B. The Emerging Hallmarks of Cancer Metabolism. Cell Metab. 2016;23:27–47. - PMC - PubMed

[9] Kruiswijk F., Labuschagne C.F., Vousden K.H. p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nat. Rev. Mol. Cell Biol. 2015;16:393–405. - PubMed

[10] Kruiswijk F., Labuschagne C.F., Vousden K.H. p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nat. Rev. Mol. Cell Biol. 2015;16:393–405. - PubMed

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The emerging regulatory roles of long non-coding RNAs implicated in cancer metabolism

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The emerging regulatory roles of long non-coding RNAs implicated in cancer metabolism

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