Targeting of extracellular protein-protein interactions with macrocyclic peptides
- PMID: 33774472
- DOI: 10.1016/j.cbpa.2021.02.013
Targeting of extracellular protein-protein interactions with macrocyclic peptides
Abstract
Targeting of extracellular protein-protein interactions (PPI) is emerging as a major application for de novo discovered macrocyclic peptides. Modern discovery platforms can routinely identify macrocyclic peptide ligands capable of highly selective modulation of extracellular signaling pathways; amenability to chemical synthesis and natural modularity of peptides additionally provides an avenue for their further structural elaboration, while the challenge of cell internalization can be minimized. Here, we discuss the recent progress in targeting extracellular PPIs with macrocyclic peptides by focusing on a number of recent case studies. We analyze the scope and potential limitations of the discovery systems in identifying functional macrocyclic ligands. We also highlight the recent technical advancements allowing for a more streamlined discovery pipeline and our brief perspective in this field.
Keywords: Drug discovery; Extracellular protein; Macrocyclic peptide; Protein protein interaction.
Copyright © 2021 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Similar articles
-
The RaPID Platform for the Discovery of Pseudo-Natural Macrocyclic Peptides.Acc Chem Res. 2021 Sep 21;54(18):3604-3617. doi: 10.1021/acs.accounts.1c00391. Epub 2021 Sep 10. Acc Chem Res. 2021. PMID: 34505781
-
Selection-based discovery of macrocyclic peptides for the next generation therapeutics.Curr Opin Chem Biol. 2015 Jun;26:34-41. doi: 10.1016/j.cbpa.2015.01.023. Epub 2015 Feb 20. Curr Opin Chem Biol. 2015. PMID: 25703142 Review.
-
Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies.Curr Opin Chem Biol. 2015 Feb;24:131-8. doi: 10.1016/j.cbpa.2014.11.011. Epub 2014 Dec 5. Curr Opin Chem Biol. 2015. PMID: 25483262 Review.
-
The Road Ahead for the Development of Macrocyclic Peptide Ligands.Biochemistry. 2020 Jan 21;59(2):139-145. doi: 10.1021/acs.biochem.9b00802. Epub 2019 Oct 16. Biochemistry. 2020. PMID: 31592645
-
A current perspective on applications of macrocyclic-peptide-based high-affinity ligands.Biopolymers. 2016 Nov;106(6):889-900. doi: 10.1002/bip.22900. Biopolymers. 2016. PMID: 27352774 Free PMC article. Review.
Cited by
-
Dual-Capped Helical Interface Mimics.J Am Chem Soc. 2024 Apr 17;146(15):10331-10341. doi: 10.1021/jacs.3c11717. Epub 2024 Apr 4. J Am Chem Soc. 2024. PMID: 38573124 Free PMC article.
-
Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis.J Org Chem. 2024 Apr 5;89(7):4261-4282. doi: 10.1021/acs.joc.3c01494. Epub 2024 Mar 20. J Org Chem. 2024. PMID: 38508870 Free PMC article. Review.
-
A Comprehensive Technology Platform for the Rapid Discovery of Peptide Inhibitors against SARS-CoV-2 Pseudovirus Infection.Int J Mol Sci. 2023 Jul 29;24(15):12146. doi: 10.3390/ijms241512146. Int J Mol Sci. 2023. PMID: 37569522 Free PMC article.
-
Modular synthesis of clickable peptides via late-stage maleimidation on C(7)-H tryptophan.Nat Commun. 2023 Jul 5;14(1):3973. doi: 10.1038/s41467-023-39703-y. Nat Commun. 2023. PMID: 37407547 Free PMC article.
-
Bioconjugate Platform for Iterative Backbone N-Methylation of Peptides.ACS Catal. 2022 Nov 18;12(22):14006-14014. doi: 10.1021/acscatal.2c04681. Epub 2022 Oct 31. ACS Catal. 2022. PMID: 36793448 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources