Understanding and optimizing the antibacterial functions of anodized nano-engineered titanium implants
- PMID: 33744499
- DOI: 10.1016/j.actbio.2021.03.027
Understanding and optimizing the antibacterial functions of anodized nano-engineered titanium implants
Abstract
Nanoscale surface modification of titanium-based orthopaedic and dental implants is routinely applied to augment bioactivity, however, as is the case with other cells, bacterial adhesion is increased on nano-rough surfaces. Electrochemically anodized Ti implants with titania nanotubes (TNTs) have been proposed as an ideal implant surface with desirable bioactivity and local drug release functions to target various conditions. However, a comprehensive state of the art overview of why and how such TNTs-Ti implants acquire antibacterial functions, and an in-depth knowledge of how topography, chemistry and local elution of potent antibiotic agents influence such functions has not been reported. This review discusses and details the application of nano-engineered Ti implants modified with TNTs for maximum local antibacterial functions, deciphering the interdependence of various characteristics and the fine-tuning of different parameters to minimize cytotoxicity. An ideal implant surface should cater simultaneously to ossoeintegration (and soft-tissue integration for dental implants), immunomodulation and antibacterial functions. We also evaluate the effectiveness and challenges associated with such synergistic functions from modified TNTs-implants. Particular focus is placed on the metallic and semi-metallic modification of TNTs towards enabling bactericidal properties, which is often dose dependent. Additionally, there are concerns over the cytotoxicity of these therapies. In that light, research challenges in this domain and expectations from the next generation of customizable antibacterial TNTs implants towards clinical translation are critically evaluated. STATEMENT OF SIGNIFICANCE: One of the major causes of titanium orthopaedic/dental implant failure is bacterial colonization and infection, which results in complete implant failure and the need for revision surgery and re-implantation. Using advanced nanotechnology, controlled nanotopographies have been fabricated on Ti implants, for instance anodized nanotubes, which can accommodate and locally elute potent antibiotic agents. In this pioneering review, we shine light on the topographical, chemical and therapeutic aspects of antibacterial nanotubes towards achieving desirable tailored antibacterial efficacy without cytotoxicity concerns. This interdisciplinary review will appeal to researchers from the wider scientific community interested in biomaterials science, structure and function, and will provide an improved understanding of controlling bacterial infection around nano-engineered implants, aimed at bridging the gap between research and clinics.
Keywords: Anodization; Bacterial infection; Local drug delivery; Nanotubes; Therapy; Titanium implants.
Copyright © 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Similar articles
-
ON or OFF: Triggered therapies from anodized nano-engineered titanium implants.J Control Release. 2021 May 10;333:521-535. doi: 10.1016/j.jconrel.2021.03.020. Epub 2021 Mar 22. J Control Release. 2021. PMID: 33766694 Review.
-
Understanding and augmenting the stability of therapeutic nanotubes on anodized titanium implants.Mater Sci Eng C Mater Biol Appl. 2018 Jul 1;88:182-195. doi: 10.1016/j.msec.2018.03.007. Epub 2018 Mar 17. Mater Sci Eng C Mater Biol Appl. 2018. PMID: 29636134 Review.
-
Tailoring the immuno-responsiveness of anodized nano-engineered titanium implants.J Mater Chem B. 2018 May 14;6(18):2677-2689. doi: 10.1039/c8tb00450a. Epub 2018 Apr 19. J Mater Chem B. 2018. PMID: 32254221
-
Research to Clinics: Clinical Translation Considerations for Anodized Nano-Engineered Titanium Implants.ACS Biomater Sci Eng. 2022 Oct 10;8(10):4077-4091. doi: 10.1021/acsbiomaterials.1c00529. Epub 2021 Jul 27. ACS Biomater Sci Eng. 2022. PMID: 34313123 Review.
-
Determining the relative importance of titania nanotubes characteristics on bone implant surface performance: A quality by design study with a fuzzy approach.Mater Sci Eng C Mater Biol Appl. 2020 Sep;114:110995. doi: 10.1016/j.msec.2020.110995. Epub 2020 Apr 21. Mater Sci Eng C Mater Biol Appl. 2020. PMID: 32993986
Cited by
-
Insight into antibacterial effect of titanium nanotubular surfaces with focus on Staphylococcus aureus and Pseudomonas aeruginosa.Sci Rep. 2024 Jul 27;14(1):17303. doi: 10.1038/s41598-024-68266-1. Sci Rep. 2024. PMID: 39068252 Free PMC article.
-
In Vitro Characterization of Hydroxyapatite-Based Coatings Doped with Mg or Zn Electrochemically Deposited on Nanostructured Titanium.Biomimetics (Basel). 2024 Apr 18;9(4):244. doi: 10.3390/biomimetics9040244. Biomimetics (Basel). 2024. PMID: 38667255 Free PMC article.
-
Innovative Anodic Treatment to Obtain Stable Metallic Silver Micropatches on TiO2 Nanotubes: Structural, Electrochemical, and Photochemical Properties.ACS Omega. 2024 Feb 15;9(8):9644-9654. doi: 10.1021/acsomega.3c09687. eCollection 2024 Feb 27. ACS Omega. 2024. PMID: 38434842 Free PMC article.
-
Nanoengineering and Surface Modifications of Dental Implants.Cureus. 2024 Jan 2;16(1):e51526. doi: 10.7759/cureus.51526. eCollection 2024 Jan. Cureus. 2024. PMID: 38304686 Free PMC article. Review.
-
Improving antibacterial ability of Ti-Cu thin films with co-sputtering method.Sci Rep. 2023 Oct 3;13(1):16593. doi: 10.1038/s41598-023-43875-4. Sci Rep. 2023. PMID: 37789153 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous