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Review
. 2021 May;473(5):723-734.
doi: 10.1007/s00424-021-02529-y. Epub 2021 Mar 19.

Is carbonyl/AGE/RAGE stress a hallmark of the brain aging?

Halyna Semchyshyn  1
Affiliations
Review

Is carbonyl/AGE/RAGE stress a hallmark of the brain aging?

Halyna Semchyshyn. Pflugers Arch. 2021 May.

Abstract

Recent studies have linked carbonyl stress to many physiological processes. Increase in the levels of carbonyl compounds, derived from both endogenous and exogenous sources, is believed to accompany normal age-related decline as well as different pathologies. Reactive carbonyl species (RCS) are capable of damaging biomolecules via their involvement in a net of nonspecific reactions. In the advanced stages of RCS metabolism, variety of poorly degraded adducts and crosslinks, collectively named advanced glycoxidation end products (AGEs), arises. They are accumulated in an age-dependent manner in different tissues and organs and can contribute to inflammatory processes. In particular, detrimental effects of the end products are realized via activation of the specific receptor for AGEs (RAGE) and RAGE-dependent inflammatory signaling cascade. Although it is unclear, whether carbonyl stress is causal for age-associated impairments or it results from age- and disease-related cell damages, increased levels of RCS and AGEs are tightly related to inflammaging, and therefore, attenuation of the RAGE signaling is suggested as an effective approach for the treatment of inflammation and age-related disorders. The question raised in this review is whether specific metabolism in the aging brain related to carbonyl/RCS/AGE/RAGE stress.

Keywords: AGE/RAGE signaling; Antiglycation system; Neuroinflammation; RAGE antagonists; Reactive carbonyl and oxygen species.

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