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. 2021 Mar 12;21(1):133.
doi: 10.1186/s12886-021-01880-z.

Dynamic monocyte chemoattractant protein-1 level as predictors of perceived pain during first and second phacoemulsification eye surgeries in patients with bilateral cataract

Feng Zhang  1   2 , Jin-Hua Wang  1 , Mei-Sheng Zhao  3
Affiliations

Dynamic monocyte chemoattractant protein-1 level as predictors of perceived pain during first and second phacoemulsification eye surgeries in patients with bilateral cataract

Feng Zhang et al. BMC Ophthalmol. .

Abstract

Background: The purpose of the study was to investigate whether dynamic monocyte chemoattractant protein-1 (MCP-1) level might be as predictors of perceived pain during the first and second phacoemulsification eye surgeries in patients with bilateral cataract.

Methods: Consecutive bilateral cataract patients undergoing bilateral sequential phacoemulsification were retrospectively enrolled. Patients' preoperative anxiety score and intraoperative pain score were registered. Aqueous humor samples were obtained during surgery. MCP-1 level in the aqueous humor was measured by enzyme linked immunosorbent assay (Elisa). Patients were assigned to seven subgroups based on the interval between first-eye and second-eye cataract surgery. Comparisons were performed for a subjective sensation and MCP-1 levels among different subgroups.

Results: pain score during second-eye surgery was significantly higher than during first-eye surgery. Whereas there was no statistical difference in anxiety score between both surgeries. Result from subgroups comparison showed that the visual analog scale (VAS) pain score was statistically greater in 1-group and 6-group during the second eye surgery. Anxiety score did not statistically differ in subgroups. Additionally, the second-eye MCP-1 level was significantly higher at week 1and 6 intervals. Preoperative MCP-1 level was positively correlated with perceiving pain score during both surgeries.

Conclusions: MCP-1 level in aqueous humor significantly correlated with perceived pain during cataract surgery. Dynamic MCP-1 level could function as predictors of perceived pain during the first and second phacoemulsification eye surgeries in patients with bilateral cataract, which might support clinicians in treatment optimization and clinical decision-making.

Keywords: Bilateral cataract surgery; CCL2; MCP-1; Pain; Predictor.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Comparison of anxiety and pain score between the first and second phacoemulsification cataract surgery. The bar in the box indicates the median. The lower and upper bars indicate the range (minimum- maximum). a STAI anxiety score, b VAS anxiety score, c VAS pain score
Fig. 2
Fig. 2
Comparison of anxiety (a) and pain score (b) (median with range) in seven subgroups established based on the interval between first-eye and second-eye cataract surgery
Fig. 3
Fig. 3
Comparison of MCP- 1levels in aqueous humor between first-surgery and second-surgery (a); Comparison of MCP-1 levels in the second eye in seven subgroups based on the interval between first-eye and second-eye cataract surgery (b)
Fig. 4
Fig. 4
Scatterplots of VAS pain score and MCP-1 levels in aqueous humor during the first-eye (a) and second-eye (b) surgeries. Pearson’s bivariate correlation analysis was used to identify the relationship
See this image and copyright information in PMC

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