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. 2021 Dec;25(4):1773-1789.
doi: 10.1007/s11325-021-02323-1. Epub 2021 Mar 11.

Association between obstructive sleep apnea and health-related quality of life in untreated adults: a systematic review

Patrícia Pauletto  1 , Jéssica Conti Réus  2 , Michele Bolan  3 , Carla Massignan  2   4 , Carlos Flores-Mir  5 , Israel Maia  6 , David Gozal  7 , Ana Luiza Curi Hallal  2 , André Luís Porporatti  2 , Graziela De Luca Canto  2
Affiliations

Association between obstructive sleep apnea and health-related quality of life in untreated adults: a systematic review

Patrícia Pauletto et al. Sleep Breath. 2021 Dec.

Abstract

Purpose: The objective of this systematic review was to answer the question: "Is there association between obstructive sleep apnea (OSA) and health-related quality of life (HRQoL) in untreated adults?"

Methods: We included observational studies that evaluated the health-related quality of life of patients with OSA vs control groups, through generic and disease-specific questionnaires. The searches were conducted in six databases: Embase, Lilacs, PsycINFO, PubMed, Scopus, and Web of Science. Additional search in the grey literature and hand search were performed, and also experts were consulted. Risk of bias was performed by using Joanna Briggs Institute Critical Appraisal Checklist for cross-sectional, cohort, and case-control studies. We analyzed the data using a narrative synthesis. The Grading of Recommendations Assessment, Development, and Evaluation evidence profile was used to verify the overall certainty of the assessed evidence.

Results: Nineteen studies were included for qualitative analysis. Generic questionnaires showed worse HRQoL in the OSA group compared to the control group in at least one domain of the HRQoL questionnaires. The affected domains that showed statistical and clinically relevant differences were physical functioning, physical role, pain, general health, vitality, emotional role, and mental health. The certainty of evidence assessment was very low.

Conclusion: The available literature suggests that OSA in untreated adults is associated with worse HRQoL. However, this association seems to disappear when we consider only studies adjusted for related covariates.

Registration: CRD42018114746.

Keywords: Health-related quality of life; Obstructive sleep apnea; Polysomnography; Systematic review.

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References

    1. Silva Gomes Ribeiro CV, Ribeiro-Sobrinho D, Muñoz Lora VRM et al (2019) Association between mandibular advancement device therapy and reduction of Excessive Daytime Sleepiness due to Obstructive Sleep Apnea. J Oral Rehabil. https://doi.org/10.1111/joor.12792
    1. Canto G, Singh V, Gozal D et al (2018) Sleep bruxism and sleep-disordered breathing: a systematic review. J Oral Facial Pain Headache 28:299–305. https://doi.org/10.11607/ofph.1294 - DOI
    1. Zimmerman ME, Aloia MS (2012) Sleep-disordered breathing and cognition in older adults. Curr Neurol Neurosci Rep 12:537–546 - DOI
    1. Senaratna CV, Perret JL, Lodge CJ et al (2017) Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev 34:70–81 - DOI
    1. Sateia MJ (2014) International Classification of Sleep Disorders-Third Edition. Chest 146:1387–1394. https://doi.org/10.1378/chest.14-0970 - DOI - PubMed

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