Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Feb 28;13(3):388.
doi: 10.3390/v13030388.

Adenovirus Core Proteins: Structure and Function

Shermila Kulanayake  1   2 , Suresh K Tikoo  1   2
Affiliations
Review

Adenovirus Core Proteins: Structure and Function

Shermila Kulanayake et al. Viruses. .

Abstract

Adenoviruses have served as a model for investigating viral-cell interactions and discovering different cellular processes, such as RNA splicing and DNA replication. In addition, the development and evaluation of adenoviruses as the viral vectors for vaccination and gene therapy has led to detailed investigations about adenovirus biology, including the structure and function of the adenovirus encoded proteins. While the determination of the structure and function of the viral capsid proteins in adenovirus biology has been the subject of numerous reports, the last few years have seen increased interest in elucidating the structure and function of the adenovirus core proteins. Here, we provide a review of research about the structure and function of the adenovirus core proteins in adenovirus biology.

Keywords: AdV protease cleavage; DNA genome; DNA packaging; adenovirus; core proteins; nucleus.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(A), Schematic diagram of the genome of Mastadenovirus (bovine adenovirus-3). Two lines show DNA strands. Numbers at the top show base pairs (BP). Arrows show the direction of transcription/translation. Core proteins are depicted in green. AVP—adenoviral protease; DBP—DNA-binding protein; POL—DNA polymerase; E—early; L—late. (B), Adenovirus structure: Schematic diagram of a cross-section of the adenovirus virion based on crystallography and cryo-electron microscopy. AVP—adenovirus protease; TP—terminal protease; p—protein. Adapted from ref. [1].
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Russell W.C. Adenoviruses: Update on structure and function. J. Gen. Virol. 2009;90:1–20. doi: 10.1099/vir.0.003087-0. - DOI - PubMed
    1. Rowe W.P., Huebner R.J., Gilmore L.K., Parrott R.H., Ward T.G. Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc. Soc. Exp. Biol. Med. 1953;84:570–573. doi: 10.3181/00379727-84-20714. - DOI - PubMed
    1. Enders J.F., Bell J.A., Dingle J.H., Francis T., Jr., Hilleman M.R., Huebner R.J., Payne A.M. Adenoviruses: Group name proposed for new respiratory-tract viruses. Science. 1956;124:119–120. doi: 10.1126/science.124.3212.119. - DOI - PubMed
    1. Shenk T. Adenoviridae: The viruses and their replication. In: Fields B.N., Knipe D.M., Howley P.M., editors. “Fields Virology”. 4th ed. Lippincott Williams & Wilkins; Philadelphia, PA, USA: 2001.
    1. Mese K., Bunz O., Schellhorn S., Volkwein W., Jung D., Gao J., Zhang W., Baiker A., Ehrhardt A. Identification of novel human adenovirus candidates using the coxsackievirus and adenovirus receptor for cell entry. Virol. J. 2020;17:52. doi: 10.1186/s12985-020-01318-w. - DOI - PMC - PubMed

Publication types

LinkOut - more resources